Search
Menu
Home
Sources
About
Contacts
EAF family
In
molecular biology
, the
EAF
family
of
proteins
act as
transcriptional
transactivators
of
ELL
and
ELL2
RNA Polymerase II
transcriptional
elongation factors
. EAF proteins form a
stable
heterodimer
complex
with ELL proteins to
facilitate
the
binding
of
RNA polymerase II
to
activate
transcription
elongation
. ELL and
EAF1
are
components
of
Cajal bodies
, which have a role in
leukemogenesis
. EAF1 also has the capacity to
interact
with ELL1 and ELL2. The
N terminus
of approx 120 of EAF1 has a region of high
serine
,
aspartic acid
, and
glutamic acid
residues
.
