Earl was born in Athens, Ohio, the third Bishop of the Methodist Church to have been born in Athens. Earl was said to have a vigorous body squarely built and above the average height for that day. Among his ancestors were Roger Williams and John and Samuel Cranston, both colonialgovernors of Rhode Island. Earl was the son of Earl and Jane E. Cranston. Earl Jr married Martha A. Behan in 1861. She died April 7, 1872. He then married Laura A. Martin, who died February 3, 1903. He then married Lucie M. Parker. Earl was the father of Earl M., Grace, James B., Dora, Ethel, Laura Alden, and Ruth.
Earl graduated High School in Jackson, Ohio. He earned the A.B. degree in 1861 and the A.M. degree in 1865, both from Ohio University. The Rev. Solomon Howard, D.D., LL.D., was the President of O.U. at the time. Earl was a member of Beta Theta Pifraternity. The Rev. William Taylor, visited Athens during Earl's college years. Taylor held revival services, in which many students, including Earl, were converted to Christ.
Earl was admitted as a Minister to the OhioAnnual Conference of the M.E. Church in 1867. He served the following appointments as Pastor: Portsmouth, 1867–69; and Columbus, 1869-70. He then was transferred to the Minnesota Conference, where he served Winona, 1870-71. He transferred again, to the Illinois Conference, where he served Jacksonville, 1871-74. He transferred again, to the Indiana Conference, where he was appointed to Evansville, 1874-75. He then transferred to the Cincinnati Conference, where he was appointed Pastor in Cincinnati, Ohio, 1875-78. In 1878, the Rev. Cranston was appointed Pastor in Denver, Colorado, a change necessitated by the health of his family. While in Denver, Dr. Cranston took a prominent part in the movement to create and establish the University of Denver. He served both as Secretary of the Board of Trustees, and as Chairman of the Finance Committee. He also spent time as a member of the faculty. In 1880, the Rev. Dr. Cranston was appointed Presiding Elder of the Southern District of the Colorado Conference, serving until 1884. During this time he covered a territory of, requiring as much as of travel each year.
Publishing agent
The 1884 General Conference of the M.E. Church elected the Rev. Cranston Publishing Agent for the Western Book Concern, headquartered in Cincinnati. The Western Book Concern included offices in Chicago, St. Louis and on the Pacific coast. During this time he resided at Avondale, Cincinnati. He held this position until 1896. The Rev. Cranston was a member of M.E. General Conferences from 1884 until 1896.