Described as a "cult favorite", Pepitone is a staple in the Los Angeles comedy scene. He is known for his regular appearances on the WTF with Marc Maron podcast and his sketch appearances on Late Night with Conan O'Brien and Conan, often playing his recurring role as the "New York City Heckler" in the audience. He has also had recurring roles on television programs such as The Life & Times of Tim, The Sarah Silverman Program and Nick Swardson's Pretend Time. His short mockumentary filmRunyon: Just Above Sunset, co-written by Karen Simmons and directed by Troy Conrad, won Best in Show at the L.A. Mockfest as well as Best Comedy Short at the Burbank Film Festival in 2011. Pepitone was a first-round contestant during the first season of Last Comic Standing. Throughout the late 1990s and early 2000s, Pepitone was a regular sketch performer on Late Night with Conan O'Brien. He has appeared in films such as The Muppets, Old School, School for Scoundrels, and Terri. Pepitone regularly performs stand-up comedy at the Upright Citizens Brigade Theater in Los Angeles. Pepitone has made many guest appearances on comedy programs such as Bob's Burgers, The King of Queens, Chappelle's Show, Monk, Community, Childrens Hospital, The Eric Andre Show, Happy Endings, Flight of the Conchords, 2 Broke Girls, Whitney and It's Always Sunny in Philadelphia. Pepitone also appears in the 2012 documentary Alone Up There that looks at the craft of stand-up comedy. Pepitone's first stand-up album, A Great Stillness, was recorded at the Gotham Comedy Club and released in 2011. He also released a sketch comedy album in 2006 called The Big Push. From 2011 to 2013, Pepitone starred in the 500 episodes of the web comedy seriesPuddin'. In the fall of 2013, Pepitone started hosting his own podcast called Pep Talks after being a member of The Long Shot podcast for several years. In 2014, he won the September 7 episode of @midnight. A documentary about Pepitone's career entitled The Bitter Buddha was released in 2012 to positive reviews. Pepitone is now starring in the Adult Swim comedy Your Pretty Face is Going to Hell. He stars as Eddie, a tortured soul.
