Ramirez has starred in a number of films, including Napoleon Dynamite as Pedro Sánchez, Employee of the Month with Dane Cook, Jessica Simpson, and Dax Shepard, Crank and with Jason Statham, Searching for Mickey Fish with Daniel Baldwin, All You've Got with Ciara, and HBO's Walkout and made cameos in Nacho Libre and Mr. & Mrs. Smith. In 2009, Efren starred in the comedyAmerican Summer with Matthew Lillard as well as appearing as a contestant on MTV's Celebrity Rap Superstar. On July 14, 2008 Sierra Mist released a series of commercials aimed at multicultural consumers in which Efren stars. The first being named "Wedding Girl" followed by "Mannequin Man" and an online spot, "The Whiner," which will be posted at the Sierra Mist dedicated site, RefreshYourMind.com Soon after the success of Napoleon Dynamite, the music group G. Love and Special Sauce asked Efren to appear in their music video "Booty Call". He also played Ashlee Simpson's boyfriend in the music video for her 2005 song "Boyfriend". Ramírez made a cameo appearance in a 2005 episode of ABC's George López wearing a T-shirt similar to the shirt Jon Heder wears in Napoleon Dynamite that reads, "Vote For Pedro". In 2007 Ramírez appeared as the judge for an acting challenge on Cycle 8 of America's Next Top Model. Ramírez made several cameos throughout his career. In King Cobra, he portrayed a teenager playing a game of hide-and-seek with his girlfriend. They later end up as prey for the title antagonist. In the music video for Sleazy, Pedro appears as a cameo and lip syncs André 3000's verse. He co-founded Powerhouse Pictures Entertainment, LLC with Chris Barrett, and they co-authored the book Direct Your Own Life: How To Be A Star in Any Field You Choose being published on June 10, 2008 through Kaplan Publishing.
Personal life
In 1998, Efren married actress Iyari Limon. The marriage was later annulled. Ramírez is also a popular DJ, who has performed worldwide and toured in over 50 cities across 5 continents. His sets include a variety of music, from hip hop, funk, disco, to hard house. His production company "Nocturnal Rampage" throws a recurring rave event every summer in Austin.
