Axtman is interested in exploring and molding historical and contemporary representations of American racialization, including the sub-themes of racial passing and the trope of the tragic mulatto. Several of her pieces involve reworking found video and audio, and she often inserts herself—her voice, her face—into her work. In noting that her work draws comedic inspiration from the likes of Richard Pryor and Paul Mooney, she has stated that: "Humor has always been a part of what I do. It helps me to talk about things, but it keeps me safe too." In her 2005 video American Classics, Axtman stares into the camera at close range and mouths the words to various racially charged film dialogues and monologues, including snippets from the 1934 movie Imitation of Life. Axtman's constant artistic forays into the rhetoric of race suited her work for Black Is, Black Ain't, a group show currently on view at the Museum of Contemporary Art Detroit. Black Is, Black Ain't, which culls its title from Ralph Ellison's Invisible Man, and which features Axtman's American Classics, seeks to examine the contemporary moment, where the cultural production of so-called “blackness” is concurrent with efforts to make race socially and politically irrelevant. The 2006 video Where’s The Party At? depicts Axtman, in a white track suit, dancing around a burning cross as the video's eponymous dance track plays in its entirety. The video was shot on the grounds of the Skowhegan School of Painting and Sculpture in Maine, where Axtman was an artist in residence in 2006. In an interview about Where's The Party At?, Axtman admitted: "I really got into the historical meaning of burning a cross... When burn it within their little crew of white people in little dresses, there’s such meaning of spirituality and brotherhood and their white pride. Then they put it in black people’s yards to 'I hate you nigger, get away.' So it has this really weird double meaning. It was really important for me to feel like I was mocking their sacredness. That was the best part for me...making a joke out of their hatred." Elizabeth Axtman is a recipient of the Skowhegan Endowment for Scholarship Foundation for her 2006 residency there, a Franklin Furnace Fund grant, and was an artist-in-residence with Harvestworks in NYC 2012. Axtman also produces paintings, drawings and mixed media works. She has cited Otabenga Jones, Kehinde Wiley, Guillermo Gomez-Pena, and Adrian Piper as artistic inspirations.