Elongation factor


Elongation factors are a set of proteins that function at the ribosome, during protein synthesis, to facilitate translational elongation from the formation of the first to the last peptide bond of a growing polypeptide. Bacteria and eukaryotes use elongation factors that are largely homologous to each other, but with distinct structures and different research nomenclatures.
Elongation is the most rapid step in translation. In bacteria, it proceeds at a rate of 15 to 20 amino acids added per second. In eukaryotes the rate is about two amino acids per second. Elongation factors play a role in orchestrating the events of this process, and in ensuring the high accuracy translation at these speeds.

Nomenclature of homologous EFs

In addition to their cytoplasmic machinery, eukaryotic mitochondria and plastids have their own translation machinery, each with their own set of bacterial-type elongation factors. In humans, they include TUFM, TSFM, GFM1, GFM2.
In bacteria, selenocysteinyl-tRNA requires a special elongation factor SelB related to EF-Tu. A few homologs are also found in archaea, but the functions are unknown.

As a target

Elongation factors are targets for the toxins of some pathogens. For instance, Corynebacterium diphtheriae produces its toxin, which alters protein function in the host by inactivating elongation factor. This results in the pathology and symptoms associated with Diphtheria. Likewise, Pseudomonas aeruginosa exotoxin A inactivates EF-2.