Emde degradation


The Emde degradation is a method for the reduction of a quaternary ammonium cation to a tertiary amine with sodium amalgam
This organic reaction was first described in 1909 by the German chemist Hermann Emde and was for a long time of great importance in structure elucidation of many alkaloids, for example that of ephedrine.
Alternative reducing agents exist for this reaction; for instance, lithium aluminium hydride.