Fujino made her professional MMA debut at Smackgirl-F: Next Cinderella Tournament 2nd stage & SG-F7 on, defeating Seri Saito by unanimous decision. Fujino obtained her second victory by defeating Eri Takahashi with an armbarsubmission in the second round on at Cross Section. On at Smackgirl 2006: Legend of Extreme Women, Fujino got her third straight win, defeating Mai Ichii via unanimous decision. Fujino's fourth bout was a first round straight armbar submission victory over Madoka Okada at Smackgirl 2007: Will The Queen Paint The Shinjuku Skies Red? on. Continuing her winning streak, Fujino defeated Anna Saito via submission in the first round on at the event K-Grace. Fujino defeated Yukiko Seki via unanimous decision at Smackgirl 2007: Queens' Hottest Summer on. At Cage Force EX: eastern bound on, Fujino got her seventh consecutive victory when she faced and defeated Yuko Yamazaki via unanimous decision. In her next fight, Fujino defeated Mei Yamaguchi by split decision on at Smackgirl 7th Anniversary: Starting Over. Ending Fujino's winning streak and breaking her undefeated record, women's MMA legend Megumi Yabushita defeated Fujino by unanimous decision on at Demolition 080721. Debuting with promotion Valkyrie at the promotion's first event Valkyrie 01, Fujino was defeated by veteran Tomomi Sunaba via unanimous decision on. In a rematch of their 2007 bout, Mei Yamaguchi defeated Fujino by unanimous decision during Valkyrie women's featherweight tournament at Valkyrie 02 on. In her fourth consecutive loss, Fujino was defeated via majority decision by Kyoko Takabayashi on at Valkyrie 05. Fujino rebounded with a victory over Anna Saito in a rematch of their 2007 fight at Valkyrie 08 on. Fujino choked Saito unconscious with a rear-naked choke in less than thirty seconds. Fujino faced Megumi Fujii at World Victory Road Presents: Soul of Fight on and was defeated by unanimous decision. Fujino made her Jewels debut against Celine Haga at Jewels 17th Ring on. She won the fight by unanimous decision. Fujino faced Mika Nagano at Jewels 18th Ring on. She won the fight by unanimous decision. Fujino challenged Jewels champion Ayaka Hamasaki in a title fight at Jewels 22nd Ring on in Tokyo. She was defeated by unanimous decision. On, Fujino made her Pancrase debut at Pancrase 247. She was scheduled to face Monica Lovato, but Lovato suffered an injury and Fujino instead faced Amber Brown. She defeated Brown by submission due to a neck crank in the second round. Fujino next faced Hyo Kyung Song at Deep Jewels 1 on. She defeated Song by submission due to a rear-naked choke in the second round. In a rematch at Deep Jewels 2 on, Fujino faced Mizuki Inoue in the opening round of the Deep Jewels lightweight title tournament. She was defeated by unanimous decision. In her North American MMA debut, Fujino faced Jessica Aguilar on June 21, 2014 at. She lost the fight via unanimous decision.
On at shoot boxing event Takeshi Road -bushido- The Fifth, Fujino started her kickboxing career with a TKO defeat at the hands of Girls S-Cup winner Rena Kubota after Kubota broke Fujino's nose and rendered her unable to come out for the third round. Debuting with kickboxing promotion J-Network with the J-Girls brand, in a result considered an upset, Fujino was defeated by 16-year-old Mizuki Inoue via unanimous decision at J-Girls Catch The Stone 9 on. On at J-Girls Catch The Stone 11, Fujino defeated Nozomi Satake by unanimous decision. On, Fujino entered the 2011 Shoot Boxing Girls S-Cup tournament. She faced Seo Hee Ham in the opening round and was defeated by majority decision. Fujino returned to J-Girls on at J-Girls 2012: Platinum's In The Ring Final and knocked out Ruri in 44 seconds.
