Uba was born on 14 December 1958 in Enugu, and attended the Boys High School in Awkunanaw. His parents originated from Uga in the Aguata LGA of Anambra State. According to some sources, . However, Concordia University have denied that Emmanuel Nnamdi Uba graduated from the institution. They admitted that their records indicate that a certain Emmanuel Uba was admitted to the institution but never completed the program.
Presidential aide
While still in the United States Uba assisted in the 1999 Presidential elections in Nigeria. Following the elections he returned to Nigeria and was appointed Special Assistant on Special Duties and Domestic Affairs to President Olusegun Obasanjo. In a September 2003 visit by Obasanjo to the United States, Uba was described as the President's right-hand man, and also the gatekeeper for people who wished to talk to the President.
Elected politician
In 2007, Uba contested in the PDP primaries for the Anambra State governorship election, and was elected in the 14 April2007 elections. However, the former governor Peter Obi challenged the election, saying that because the courts had only accepted that Obi had won the April 2003 elections on 15 March 2006, he still had three more years or his four-year term to serve. The courts accepted this argument and on 14 June 2007 nullified Andy Uba's election. In November 2009 it was reported that Uba was planning to run for the delayed Anambra State gubernatorial elections in February 2010 on the Labour Party platform, after the Labour party had invited him to make the move. The party's leadership said they "believed that he will deliver on the ideals and objectives of the party". Speaking about his decision to switch parties, on 31 December 2009 Uba said "Labour is my natural political home". In the February 2010 elections, Uba came in third.
2011 Senate election
Uba returned to the PDP and was nominated as PDP candidate for Anambra South Senatorial district in the April 2011 elections. He won with 63,316 votes, ahead of Chukwmaeze Nzeribe of the All Progressives Grand Alliance with 43,798 and the incumbent senator Ikechukwu Obiorah of the Accord party with 24,724. Uba's election was challenged by Senator Obiora, the Accord candidate, who claimed that Uba had forged his West African School Certificate and had not obtained any of the university degrees that he claimed. The story of allegedly faked degrees dates back to a story written by two investigative reporters and published by The News in December 2006. Reporters claim that both Concordia and California State University said that although Uba enrolled, he did not graduate from either university.