Epithelioid trophoblastic tumour

Signs and symptoms

• Vaginal bleeding: The most common presenting symptom is vaginal bleeding, which is associated with mild elevation of serum β hCG
• Amenorrhea.

  Morphology

Gross appearance

• There is deep infiltration of the surrounding structures by cystic hemorrhagic masses or discrete nodules.
• Necrosis is present with white to tan-brown cut surface with hemorrhage.
• Ulceration
• Fistula

  Microscopic appearance

• Nodular, well circumscribed, focal infiltrative at the periphery.
• Uniform, mononucleate tumor cells are arranged in nests and cords.
• Tumor nests are associated with eosinophilic, fibrillar, hyaline-like material.
• Extensive necrosis with irregular contours.
• Calcification
• Metaplastic endocervical or endometrial surface epithelium into squamous-like epithelium.

  Locations

• Uterus
• *Lower uterine segment
• *Cervix
• Lungs

• Vagina
• Broad ligament
• Fallopian tubes
• Other pelvic organs

  Diagnosis

Treatment

Prognosis