Estradiol pivalate
Estradiol pivalate, also known as estradiol trimethyl acetate and sold under the brand name Estrotate, is an estrogen medication and an estrogen ester; specifically, the C3 pivalic acid ester of estradiol. It was marketed as an oil solution for intramuscular injection in the 1940s and 1950s. A combination of estradiol pivalate and progesterone in oil solution for intramuscular injection was available in 1949.
The duration of biological effect of estradiol pivalate in women has been studied. It has been found to stimulate the vaginal epithelium in postmenopausal women, with a minimally effective dose of 0.16 mg and a maximally effective dose of 0.5 mg, both by intramuscular injection. Its effect lasted for about 4 weeks at a dose of 0.16 mg and for more than 7 weeks at a dose of 3.3 mg.
Menotrope was an oral tablet that contained 0.33 mg estradiol pivalate, 80 mg choline bitartrate, 0.46 mg folic acid, and 1.25 μg cyanocobalamin and was used in menopausal hormone therapy.
test grade with different doses of estradiol pivalate in oil solution by intramuscular injection in women. There were 10 to 20 women in each dose group.
