Enwerem served as chairman of the Nigerian Airports Authority NAA between 1980 and 1983. He was elected governor of Imo State in 1991 during the failed Third Republic era of Nigerian government. Enwerem was elected to the Nigerian Senate in 1999 to represent the Imo-East Senatorial Zone He became the first President of the Nigerian Senate during Nigeria's Fourth Republic. Enwerem beat his chief rival, Senator Chuba Okadigbo, for the Senate presidency on 3 June 1999. Former Nigerian PresidentOlusegun Obasanjo backed Enwerem for President of the Senate against Okadigbo. With the support of the Obasanjo's allies in the governing parties, plus support from two Nigerian opposition parties, Enwerem easily defeated Okadigbo with 66 votes to Okadigbo's 43 votes. Enwerem did not hold the post of President of the Nigerian Senate for very long. A Nigerian Senate committee began investigating Enwerem for allegations of corruption in 1999. The allegations against Enwerem alleged that he falsified his name, and caused a controversy as to whether Enwerem's actual real name was Evan or Evans. Enwerem was removed from office on 18 November 1999, in an ouster spearheaded by allies of Chuba Okadigbo. However, though removed as President of the Senate, Enwerem remained a member of the Senate until 2003. Okadigbo, Enwerem's rival and successor as President of the Senate, was in turn removed from office on 8 August 2000. Following Okadigbo's 2000 ouster, Enwerem briefly expressed interest in again assuming the presidency of the Senate. However, Enwerem withdrew from the race in favor of Senator Adolphus Wabara at the shadow election conducted by PDP Senators in Senate Hearing Room One. Enwerem ultimately served as a Nigerian Senator from 1999 until 2003 before leaving office. According to news reports, Enwerem expressed an interest in "good laws" whose "ripple effects on the populace would be wide, sweeping and enduring."
Death
Enwerem had been in poor health before his death in 2007. He had been hospitalized at National Hospital in Abuja, Nigeria for some time. According to reports, Enwerem's family tried to make arrangements to transfer him to a hospital in Germany for medical treatment. The National Hospital initially refused his family's request, citing Enwerem's poor health. The National Hospital finally relented and released Enwerem to his family for transfer to Germany on 1 August. on a private air ambulance to Germany, the two German doctors who arrived in the air ambulance refused to allow Enwerem to board the aircraft due to his "very critical" condition, that he was not strong enough to make the flight and rushed him back to the `national Hospital, Enwerem was readmitted to National Hospital the same day, and plugged into a ventilator machine. Enwerem died the next morning on 2 August 2007, at the National Hospital in Abuja at the age of 73. He is survived by his wife Vivienne, and seven children. One of his children, Mr Evan Enwerem jnr, has been appointed as Transition Committee Chairman of Ikeduru LGA. The then President of the Senate, David Mark, learned of the news of Enwerem's death. Mark declined to formally announce the news to the Senate because most of Enwerem's family were out of the country at the time. The then Speaker of the Nigerian House of Representatives, Patricia Olubunmi Etteh, issued a statement through her adviser, Funke Egbemode, saying that Enwerem's death "would leave a gaping hole in the nation's legislative history."
