Having competed in karts until 2005, Crestani moved up to the Formula Junior 1600 Italia championship, finishing in 4th place in the championship, driving for PSR Motorsport. Crestani had one win and finished behind Pasquale Di Sabatino, Mihai Marinescu and Jaime Alguersuari in the championship. He also made his debut in the Italian Formula Three Championship for Corbetta Competizioni at the final round at the Misano World Circuit. Having qualified 7th for both races, Fabrizio recorded a sixth and a seventh from the two races, allowing him to finish 13th in the championship. Crestani moved up full-time to Italian F3 for 2006, continuing with Corbetta Competizioni. Over the course of the season, he recorded one pole position at Vallelunga, and five podiums on his way to fifth in the championship. He also made an appearance in the British Formula 3 Championship when the series visited Mugello. Driving in the Invitational Class, he finished both races outside of the points recording a 15th and a 14th with lap times matching the National Class runners. A third season of Italian F3 followed, again with Corbetta. Having recorded two more pole positions at Misano, Crestani finally recorded his first wins in the championship at Mugello, leading home 2008 champion Mirko Bortolotti in both races. A third win would follow later in the year at Vallelunga, but Crestani could not improve on his championship position from 2006 by again finishing fifth, 41 points behind champion Paolo Maria Nocera. Crestani would not return to the series for 2008, instead moving to the Euroseries 3000 championship for GP Racing. Again, a fifth place championship position was the net result of the season including wins at Mugello, and a double at the Magione season finale. He finished 8th in the counterpart Italian series, which ran at the same time as the Euro series, at four of the first five rounds. He also forayed into the International Formula Master series, racing at Valencia, Pau and Brno for Euronova Racing. His best finish was first in the race at Pau – holding off champion Chris van der Drift by 0.058 seconds, giving him a total of 0.5 points in the championship. After Tiago Monteiro acquired the former BCN Competición team and renamed it as Ocean Racing Technology, Monteiro replaced both drivers from round one, hiring Yelmer Buurman and Crestani to be the drivers to replace them from round two of the 2008–09 GP2 Asia Series season onwards. He scored no points and finished 28th in the championship. He resumed his Euroseries career with the TP Formula team, although he then switched to the Emmebi Motorsport outfit for the final round of the championship. He took six podium finishes, a pole position and a fastest lap from the 13 races to finish fourth in the championship and fifth in the concurrent Italian F3000 championship. Crestani had a fragmented 2010, competing four races in Auto GP for the DAMS and Trident teams, and six races for David Price Racing in the main GP2 Series after replacing Giacomo Ricci in the team. Due to lack of sponsorship, Fabrizio Crestani then undertook a full 2011 season in Auto GP with the Lazarus team alongside compatriot Fabio Onidi; he finished fourth in the championship. Crestani remained with Lazarus as the team made its GP2 Series début in 2012, and was partnered by Giancarlo Serenelli. He has since scored his best series points with a second-place finish in the season-opening feature race in 2013. Reputed by racing insiders to be one of the fastest drivers who is already ready to compete in the Formula One category, Fabrizio Crestani who is presently racing with Team Lazarus is nonetheless very busy looking for a potential sponsor given that his dream is to compete for a Formula One team.
