Fenoprofen Fenoprofen is a nonsteroidal anti-inflammatory drug . Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis , osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the US as Nalfon.cost for a typical month of medication in the United States is 50 to US$100.Pharmacology Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.Contraindications History of significantly impaired renal function ; patients with known hypersensitivity to any component of the product; patients who have experienced asthma , urticaria , or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft surgery .Drug interactions Aminoglycosides : Plasma aminoglycoside levels may be elevated. Angiotensin-converting enzyme inhibitors: Antihypertensive effect of ACE inhibitors may be diminished. Anticoagulants: Coadministration may prolong prothrombin time . Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended. Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides. Hydantoins, sulfonamides , sulfonylureas: Fenoprofen may displace these drugs from their binding site . Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity . Methotrexate: May increase methotrexate levels. Phenobarbital: May decrease fenoprofen t ½. Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn. SSRIs : The risk of GI effects may be increased. elevation in free and total serum T 3 as measured by Amerlex-M kit.Brand names
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