Upon application of pressure to the internal end of the cervix, oxytocin is released, which stimulates uterine contractions, which in turn increases pressure on the cervix, until the baby is delivered. Sensory information regarding mechanical stretch of the cervix is carried in a sensory neuron, which synapses in the dorsal horn before ascending to the brain in the anterolateral columns. Via the median forebrain bundle, the efferent reaches the PVN and SON of the hypothalamus. The posterior pituitary releases oxytocin due to increased firing in the hypothalamo-hypophyseal tract. Oxytocin acts on the myometrium, on receptors which have been upregulated by a functional increase of the estrogen-progesterone ratio. This functional ratio change is mediated by a decrease in myometrial sensitivity to progesterone, due to a decrease in progesterone receptor A, and a concurrent increase in myometrial sensitivity to estrogen, due to an increase in estrogen receptor α. This causes myometrial contraction and further positive feedback on the reflex. Studies among ewes demonstrated that it is blocked by epidural anesthesia. In their studies among mice, Niles Newton and colleagues demonstrated the importance of cortical influences. They enlarged the topic by introducing the term fetus ejection reflex. The concept of cortical influences provided reasons to raise questions about the process of parturition among humans, characterized by a high encephalization quotient. Odent had observed that, in situations that are exceptionally rare, women can occasionally experience such a reflex, characterized by a birth after a short series of irresistible and powerful contractions without any room for voluntary movements. For such a hormonal cascade to occur, requires sufficient psychological safety, as occurs in normal or undisturbed birth. The higher the intervention rate, such as induction or caesarian section, the lower the likelihood of the Ferguson Reflex occurring. In contrast, the lower the incidence of intervention, such as is found in those , and birth centres worldwide, the higher the likelihood of the Ferguson Reflex occurring. This may explain the lack of research, considering the publichealth benefits of such education to both hospitals and the general public.
