On 15 February 2007, he was given the personal title of archbishop and appointed president of the Pontifical Council for Legislative Texts. Since 2008, at the direction of Pope Benedict, one of his principal responsibilities has been the revision to procedures for handling clergy sex abuse and the applicable punishments. In 2014, he explained: "We want to make this delicate material more accessible, more understandable and easier for bishops to apply." At issue is "Book VI: Sanctions in the Church". Coccopalmerio was reported to have been one of the senior cardinals who, in preparing to announce the lifting of the excommunications of four leaders of the Society of Saint Pius X in January 2009, failed to take account of recent reports that one of them, Bishop Richard Williamson, was a Holocaust denier. He was appointed a five-year renewable term as a member of the Congregation for the Doctrine of the Faith on 23 December 2010. On 18 February 2012, Pope Benedict XVI created him cardinal-deacon of San Giuseppe dei Falegnami. On 21 April 2012, Cardinal Coccopalmerio was named a member of the Congregation for the Doctrine of the Faith, the Apostolic Signatura, and the Pontifical Council for Promoting Christian Unity. On 22 December 2012, he was appointed a member of the Congregation for the Causes of Saints. He can hold these memberships until his 80th birthday. At the Synod of Bishops on New Evangelization in October 2012, Coccopalmerio argued that ecumenical efforts to further unify Christians across sectarian lines could play a pivotal role in countering the ongoing "de-Christianization" of Europe by presenting "an extraordinary sign to Islam" of Christian solidarity.
2013 Papal Conclave
In the meetings of cardinals that preceded the papal conclave of March 2013, Cardinal Coccopalmerio proposed to create a moderator of the Curia, a prelate who would identify inconsistencies and devise methods of ensuring consistency among departments of the Roman Curia that sometimes contradict one another. The idea was widely appreciated by some cardinals but some were wary that such an appointment would act as a "vice-pope" that would effectively set Vatican and Curial policy or duplicate the already considerable authority of the Substitute in the Secretariate of State, who already fills the role of the Pope's "chief of staff". In advance of that conclave, he said: "It's time to look outside Italy and Europe, in particular considering Latin America." He was one of the cardinal electors who participated in the 2013 papal conclave that elected Pope Francis, and was mentioned in the Italian press as a possible pope. According to one report, he received more votes in the conclave than any other Italian cardinal because of his proposal for reform of the Roman Curia.
On 27 August 2014, Pope Francis named him to a working group tasked with speeding up the process for assessing the nullity of a marriage. Its work resulted in changes implemented by Francis in September 2015, which eliminated obligatory appeals, eased the dismissal of appeals in certain instances, and instituted a shorter process in some cases. Following the first session of the Synod on the Family held in October 2014, he expressed disappointment that not all the participants addressed the pastoral needs of those "who are suffering through problems connected to their relationships" and instead "showed that they simply wanted to reaffirm the doctrine". He provided an example: He also endorsed the idea of access to the Eucharist for some Catholics in irregular marital situations. He offered the example of a woman who lives with a man who has three small children by a wife who abandoned him. He imagined her coming to Communion "during her father’s funeral Mass, or the day of one of the children’s confirmation". Fearing the consequences of asking her to abandon the man and the children, he asked: "So would it really be totally impossible to admit her to communion? In admitting her to communion, would I be going against the doctrine of the indissolubility of marriage? I really don’t think so: In fact, this has to do with a case of exception."
Roman Curia work under Pope Francis
In January 2015, Pope Francis named Coccopalmerio to a new board of review within the Congregation for the Doctrine of the Faith that reviews appeals from clergy found guilty of sexual abuse of minors. In 2015, Cardinal Coccopalmerio questioned the scope of the authority given to the Secretariat for the Economy and its prefect Cardinal Pell. These questions involved not the demand for transparency in all financial operations, but the consolidation of management under the Secretariat for the Economy. In 2017, he said provisions of Amoris Laetitia allow people in irregular marriage access to the sacraments only if they recognize their situation is sinful and desire to change it. The fact that such a couple also believes changing the situation immediately by splitting would cause more harm and forgoing sexual relations would threaten their current relationship does not rule out the possibility of receiving sacramental absolution and Communion.
Resignation
A month after Coccopalmerio's 80th birthday, Pope Francis accepted his resignation and named Filippo Iannone to succeed him.
Affairs and allegations
The Capozzi affair
In June 2017, news surfaced that at some point during the month, Msgr. Luigi Capozzi, the private secretary to Cardinal Francesco Coccopalmerio, had been arrested by Vatican police after illegally using cocaine at a gay orgy party at his Vatican apartment. He was afterwards hospitalized at the Roman Pius XI clinic so that he could detox. After that, he had a short period of retreat at a nearby monastery and then spent time at the Gemelli Hospital in Rome. Despite the fact that Capozzi resided in the apartment, the apartment was owned by Coccopalmerio. Prior to the arrest, Coccopalmerio had also recommended having Capozzi appointed as a Bishop. A Jerusalem Post article dated July 24, 2019 revealed that following his arrest, Capozzi was ordered to undergo drug rehabilitation therapy and was no longer in the Vatican, but rather a spiritual retreat somewhere in Italy.
The Inzoli affair
In the of the German Catholic journal , , a German theologian and editor of the said journal reported that, according to his own sources, it was Cardinal Coccopalmerio who approached the Pope in favor of the child abuser Don Mauro Inzoli in order to have him partially reinstated as priest. Leven also alleged that Coccopalmerio is known in Rome for generally opposing the removal of culprit priests from the priesthood, which for him is akin to the “death penalty”.