Fucosylation
Fucosylation is the process of adding fucose sugar units to a molecule. It is a type of glycosylation.
It is important clinically, and high levels of fucusylation have been reported in cancer.
It is performed by fucosyltransferase enzymes.
Fucosylation has been observed in vertebrates, invertebrates, plants, bacteria, and fungi. It is known to facilitate various functions including cellular adhesion and immune regulation. Fucosylation inhibition applications are being explored for a range of clinical application including some associated with sickle cell disease, rheumatoid arthritis, tumor inhibition, and chemotherapy improvements.
