GSK1360707F


GSK1360707F is a potent and selective triple reuptake inhibitor. structurally related to amitifadine and NS-2359.

Synthesis

  1. BOC Protecting group.
  2. Enolization and trapping with triflate group.
  3. Suzuki reaction
  4. Reduction
  5. Trifluoroacetic acid removal of protecting group.
  6. Simmons–Smith reaction cyclopropanation.
  7. Williamson ether synthesis.

    Transporter occupancy

GSK1360707F has recently been tested on baboons & humans for transporter occupancy using PET.