G protein-coupled receptors database


GPCRdb contains data, web tools and diagrams for G protein-coupled receptors. It stores a manual annotation of all GPCR crystal structures, the largest collections of receptor mutants and reference sequence alignments. The tools run directly in the web browser allowing for swift analysis of structures, sequence similarities, receptor relationships, homology models, drug trends, genetic variants and ligand target profiles. Diagrams illustrate receptor sequences and relationships.

Background and development

The GPCR database, GPCRdb was started in 1993 by Gert Vriend, Ad IJzerman, Bob Bywater
and Friedrich Rippmann. Over two decades, GPCRdb evolved to be a comprehensive
information system storing and analysing data. In 2013, the stewardship of
GPCRdb was transferred to the David at the University of
Copenhagen, backed up by an international team of contributors and developers
from the EU COST Action ‘’.
Today, GPCRdb offers reference data and easy-to-use web tools and diagrams for
a multidisciplinary audience investigating GPCR function, drug design or
evolution.

Content and features

A visual overview
can be seen in the GPCRdb .
The GPCRdb browsing system is structured on the following data content:
Each above menu item has subsections for data and tools.

Future directions

As part of
two orphan GPCR
funded by the European Research Commission and the Lundbeck Foundation,
respectively, the GPCRdb will deposit data and develop computational tools for
identification of endogenous and surrogate GPCR ligands. GPCRdb aims to grow
from and enable new progress in GPCR structure, function and ligand design. It
crosslinks to GuideToPharmacology
database and has adopted the official receptor naming
nomenclature, has exchange with GPCR , and has also recently become part of the set out to generate an
unprecedented number of crystal structures. Academic and industrial groups are
welcome to contact us with suggestions of joint
development or data deposition.