Gabriella Campadelli-Fiume


Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry. She is a retired professor of virology from the University of Bologna, located in Italy.

Education and research

Gabriella Camapadelli-Fiume completed her Doctorate of Science at the University of Bologna, Italy. Her specialization in virology was completed at the University of Bologna, as well. Campadelli-Fiume primarily researches Herpes Simplex Virus, particularly how HSV enters, assembles, and exits the cell during an active infection. In addition, she is interested in how HSV is induced to enter the exocytic pathway.

Primary focus

consists of two types:
FamilyHerpesvirdae
Baltimore ClassificationGroup I
Genus SimplexvirusHuman Herpes simples virus type 1
Genus SubfamilyAlphaherpesvirinae

Major discoveries

Campadelli-Fiume's discovery of nectin as the receptor for Herpes Simplex Virus, is one of her greatest accomplishments. Through her research, she also discovered the triggering activity of receptor- bound gD. In addition to these major discoveries, she uncovered the identity of the gF profusion domain, which provided the first evidence that retargeted HSVs exert anti-tumor activity.

Additional contributions to birology

Gabriella Campadelli-Fiume took part in a study published in the Journal of Virology published on August 5, 2009. The purpose of their research was to understand which glycoproteins were involved in the herpes simplex entry and fusion. Their findings indicated that the gD, gB, and gH/gL glycoproteins permit the herpes virus to enter the cell. Their research indicated that gD is not required for the interactions between the glycoproteins gB and gH/gL. Rather, their interactions are made possible due to the multiple sites carried by gB. The multiple sites of gB can be found in the pleckstrin-domain that carries the bipartite fusion loop, and interaction with gH/gL can take place successfully without gD.

Influence

Women have made significant progress towards equality within scientific fields of work. However, as efforts to increase women's participation in science fields, inequality exists. Furthermore, an underrepresented group of women remain in these fields. Campadelli-Fiume is an influential woman who continues to bridge the gender gap within the scientific community. Her achievements throughout her career have earned substantial amounts of attention and credible recognition globally. As the author of an overall encyclopedic of basic virology and clinical manifestations, Human Herpesviruses, her work has been included in the University of Pennsylvania’s 2007 Celebration of Women Writers. She has gained recent attention for applaudable women in science by the International Society of Antiviral Research that has featured her as a prominent woman scientist. The American Academy of Microbiology awarded recognition of her scientific achievement and her contributions to advanced microbiology. Campadelli’s profound research, leadership principles, scientific achievements, and passion for virology, continue to convey a powerful impression to those within the scientific community. Her influence as a female scientist plays an important role to increasing the status of women in research.

Leadership

Gabriella Campadelli-Fiumme is an active member and leader in the scientific community.

Awards

Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus
Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB
AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain
Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain
Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies
A Herpes Simplex Virus Recombinant That Exhibits a Single-Chain Antibody to HER2/neu Enters Cells through the Mammary Tumor Receptor, Independently of the gD Receptors
Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
Hydrophobic α-Helices 1 and 2 of Herpes Simplex Virus gH Interact with Lipids, and Their Mimetic Peptides Enhance Virus Infection and Fusion
The Egress of Herpesviruses from Cells: the Unanswered Questions
The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane α-Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family
Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression
Entry of Herpes Simplex Virus Mediated by Chimeric Forms of Nectin1 Retargeted to Endosomes or to Lipid Rafts Occurs through Acidic Endosomes
The Herpes Simplex Virus JMP Mutant Enters Receptor-Negative J Cells through a Novel Pathway Independent of the Known Receptors nectin1, HveA, and nectin2