Clifton-Brown, the son of Robert and Elizabeth Clifton-Brown, was born in Cambridge. He was educated at Tormore School, in Upper Deal, Kent and then Eton College, before attending the Royal Agricultural College where he qualified as a chartered surveyor in 1975. He began his career as a graduate estate surveyor at the Property Services Agency in Dorchester and, later in 1975, became an investment surveyor with Jones Lang Wootton. He became the vice chairman of the Norfolk North Conservative Association in 1984. He was elected as Constituency Chairman in 1986, a position he held until he resigned in 1991 in order to stand for election as a Conservative candidate.
Parliamentary career
During 1991, Clifton-Brown was selected as the candidate for the then Conservative parliamentary constituency of Cirencester and Tewkesbury, following the retirement of the former Cabinet minister Nicholas Ridley. He retained the seat at the 1992 general election, with a majority of 16,058, and made his maiden speech on 12 June 1992. When newly elected he became a member of the Environment Select Committee, where he remained until 1995. Clifton-Brown was then appointed as the Parliamentary Private Secretary to Douglas Hogg, the Minister of Agriculture, Fisheries and Food. Later his constituency was abolished, but he contested and was elected for the newly drawn constituency of Cotswold at the 1997 general election and returned to Parliament as a backbencher, whilst William Hague was the Leader of the Opposition. After Iain Duncan Smith became leader of the Conservative Party, Clifton-Brown became the Shadow Minister for Local and Devolved Government Affairs in 2002. After the 2005 general election, he retained the seat of Cotswold and returned to Westminster as assistant Chief Conservative Whip. On the accession of David Cameron as Leader of the Conservative Party, he was appointed the Shadow Minister for Foreign Affairs, Trade and Investment. After the 2010 election and the formation of the subsequent Coalition Government, Clifton-Brown returned to the back benches, also making overseas visits in his role as Chairman of the Conservative Party's International Office. At this time he became the Parliamentary Chairman of the Conservative Friends of the Chinese. In January 2016, the Labour Party unsuccessfully proposed an amendment in Parliament that would have required private landlords to make their homes "fit for human habitation". According to Parliament's register of interests, Clifton-Brown was one of 72 Conservative MPs who voted against the amendment who personally derived an income from renting out property. The Conservative Government had responded to the amendment that they believed homes should be fit for human habitation but did not want to pass the new law that would explicitly require it. In 2009 Clifton-Brown was criticised for claiming a second home allowance after switching his main residence from his Cotswold home to his flat in London. In 2018 he was honoured as a Knight Bachelor for political and public service. In 2019, Clifton-Brown was asked to leave the Conservative Party Conference being held in Manchester, after a dispute with security staff who prevented him from entering a meeting room with a guest who did not have a relevant identification pass. According to a BBC news report. He later apologised and described the incident as a "minor verbal misunderstanding."