Read's initial assignments were in the American West, and his first posting was with the 16th Infantry Regiment. A few months later he transferred to the 5th Cavalry Regiment, with which he served until 1889. From 1889 to 1893, Read was Assistant Professor of Military Science at the University of Iowa, after which he returned to the 5th Cavalry Regiment in Texas. In 1898, Read authored The Automatic Instructor: A Practical System for Home Study.
At the start of the Spanish–American War Read was assigned to an Ordnance unit, with which he served in Cuba until 1899. Receiving promotion to Captain, he served in New Mexico from 1901 to 1902, after which he was assigned to the Philippines.
Post-Spanish–American War
After leaving Cuba, Read served in California and Hawaii. From 1905 to 1909 he served on the Army's General Staff. Promoted to Major, he served in Cuba, Puerto Rico and the Philippines before attending the Army War College, from which he graduated in 1914.
In April, 1917, Read was appointed to head recruiting as the Army began to mobilize for World War I. In August he was selected to command the 152nd Depot Brigade at Camp Upton, New York. In December Read was promoted to temporary Major General and assigned to command first the 77th Infantry Division, and then the 15th Cavalry Division in El Paso, Texas. The 15th Cavalry Division was disbanded in favor of fielding all Infantry divisions, and in April, 1918 Read took command of the 30th Infantry Division, which he led to France. In June he was selected to command the II Corps, consisting of five divisions assigned to the British sector of the Western Front. After three of his divisions were transferred to take part in the Saint-Mihiel Offensive, Read continued to command the other two divisions, which were attached to the Australian Corps in the Ypres sector, and participated in the Hundred Days Offensive that breached the Hindenburg Line. Read continued to command the II Corps after the Armistice. After the organization was demobilized in February, 1919 Read was assigned to command of the American Embarkation Center at Le Havre, France, where he was responsible for arranging the transportation of men and materiel back to the United States. He was also the final commander of the 42nd Infantry Division as it completed post-war occupation duty in Germany and prepared to depart Europe.
Post–World War I
In May, 1919, Read was assigned to command the US V Corps at Camp Jackson, South Carolina with the permanent rank of Brigadier General. In March, 1921 he received permanent promotion to Major General. In October, 1922, Read was appointed commander of the Philippine Department. He assumed command in early 1923, and remained in this assignment until his 1925 retirement.
In 1886, Read married Burton Young in a ceremony that took place in El Paso. She was the daughter of General S.B.M Young, who served as the first Army Chief of Staff. Their children included Burton Young Read, a career soldier who served from the early 1900s through World War II before retiring as a Colonel, and George Windle Read Jr., a career soldier who served in both world wars and attained the rank of Lieutenant General as commander of the US Army Armor Center and the Second United States Army.