SR 133 begins at an intersection with US 84/US 221/SR 38/SR 94 in Valdosta, within Lowndes County. It has an interchange with Interstate 75 before passing through Troupville and crossing over the Withlacoochee and Little rivers, the latter one marksing the Lowndes–Brooks county line. It heads northwest to Morven and an intersection with SR 76. It continues northwest to SR 122 and SR 333. A short distance later, it enters Colquitt County. The road passes through the town of Berlin, and past the Spence Airport, before it reaches Moultrie. In town, it first meets US 319/SR 35 and SR 37. SR 37/SR 133 join the concurrency to the north. A short distance later, SR 37 departs to the northeast The concurrency curves to the northwest to meet the northern terminus of US 319 Business. At this intersection, US 319/SR 35 depart to the northeast, while SR 33 joins SR 133 to the northwest. The highways split, and SR 133 travels through rural areas of the county until it reaches Doerun. In town, it has an intersection with SR 270 Spur. Less than later, it joins SR 270 in a concurrency to the west. At North Broad Street, the highways split, with SR 133 continuing to head west. Northwest of Doerun, the road enters Worth County. It travels through rural areas of the county, before it crosses into Dougherty County. It continues to the northwest until it enter Albany. In Albany, it has an interchange with US 19/SR 3/SR 300. This interchange marks the eastern terminus of SR 234. US 19/SR 3/SR 133/SR 300 head north on the Liberty Expressway. They meet US 82 Business/SR 520 Business. This interchange also marks the southern terminus of US 19 Business. Less than later, SR 300 leaves the concurrency, and US 82/SR 520 join it. The concurrency curves to the northwest and crosses over the Flint River. The next interchange is SR 91, where SR 133 departs the concurrency. Almost immediately, SR 91 leaves to the northeast, and SR 133 continues to the northwest. It crosses over the western part of Lake Worth. Almost immediately the highway enters Lee County. Finally, it continues northwest for a little while until it meets its northern terminus, an intersection with US 19/SR 3, north of Albany. All of SR 133 from its southern terminus in Valdosta until the point it leaves the Liberty Expressway in Albany is part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.
Future
Urban stretches of SR 133 are four-laned and undivided. Rural stretches of the route are currently two-laned. The GDOT has plans to widen all rural stretches of SR 133 by 2018.
Major intersections
Related route
State Route 133 Alternate is a connector route that exists entirely within the central part of Colquitt County. It is known as Old Doerun Road for its entire length. It begins at an intersection with US 319 Business/SR 33 in downtown Moultrie. It heads west and curves to the northwest to meet SR 111 in the northwest part of the city. The highway travels through rural areas until it meets the SR 133 mainline in a rural part of Colquitt County, northwest of Moultrie. SR 133 Alternate is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.
