SR 88 begins at an intersection with SR 24/SR 540, just east of Sandersville, in the central part of Washington County. At this intersection, it begins a concurrency with SR 540. The two highways head northeast to an intersection with the northern terminus of SR 231 and the southern terminus of Tree Nursery Road, north-northwest of Davisboro. This is just before the highways cross over the Ogeechee River on the Fenns Bridge into Jefferson County. Not too far into the county is an intersection with SR 171. South of Stapleton is SR 296. SR 88 and SR 540 continue to the northwest, until they meet US 1/US 221/SR 4/SR 17 in the extreme southwestern part of Wrens. The six highways travel concurrently to the north-northeast into the main part of the city. At an intersection with the western terminus of Howard Street and the southern terminus of Thomson Highway, SR 17 departs to the north-northwest onto Thomson Highway. A few blocks later, they intersect SR 80. At this intersection, SR 80/SR 88 head to the east. At Waynesboro Road, SR 80 departs to the south-southeast, while SR 88 continues its east-northeastern routing. Then, it gradually curves to a near-due-eastern direction, before heading southeast at Matthews. After that, it heads east-northeast, and then northeast, until it enters Burke County, just before it meets SR 305. Here, it heads north-northeast, and straddles the county line for a short distance, into Keysville. The highway briefly heads north-northwest before it turns to the northeast and enters Richmond County and the city limits of Augusta. After a brief portion in the city, it enters the city ofBlythe. Here, the path of SR 88 and that of US 1/SR 4/SR 540 come very close together, forming the shape of the letter "K", but with a very short horizontal line connecting its upright parts. The two highway paths do not actually intersect, as there is a very brief connecting road inbetween. SR 88 curves to the east-northeast and re-enters Augusta. It curves to the east-southeast and enters Hephzibah. On the northeastern edge of the city, on the Hephzibah–Augusta line, it meets its eastern terminus, an intersection with US 25/SR 121. The only portion of SR 88 that is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense, is the entire SR 540 concurrency, from east of Sandersville to Wrens.