D'Antonio was born in a peasant community in the mountain village of Bolognola between 1415 and 1420. His father was known as Antonio di Domenico "the madman". The first records of Giovanni Angelo d'Antonio date from 1443, after he had just made a trip to Florence that included a meeting with Giovanni di Cosimo de' Medici. After a second visit in 1444, he returned to Camerino to produce his first notable work, Madonna e santi , now at Palazzo di Venezia in Rome. The picture, painted for the church of San Michele Arcangelo di Bolognola at which his brother, don Pietro, was the priest from 1441, shows the influence of the Florentine School and of Filippo Lippi in particular. In 1449 he was commissioned to work on a fresco for a chapel in Sant'Agostino in Camerino. It is hypothesised that he may have made a visit to Padua with his friend and fellow Camerino school painter Giovanni Boccati, which would explain the change in his style in the 1450s. His most significant work is considered to be the Annunciazione from the convent at Spermento, most likely commissioned by Elisabetta Malatesta da Varano, and painted between 1455 and 1456. His most successful period followed, lasting into the 1460s, during which his understanding of way in which Piero della Francesca was using light is evident. Works from this period include the Crocifissione e santi at Castello di Fiordimonte, the Madonna e santi from church of San Francesco, and the Madonna della Misericordia at Villa di Montalto. His final major piece was undertaken in his seventies. He returned to work in his small home town to fresco a Madonna and child with various saints in a roadside shrine near Bolognola. The shrine frescoes have now been removed to the Pinacoteca Civica in Camerino and restored. Giovanni Angelo d'Antonio made his last Will and testament in 1478 and was dead by 1481. Until a radical reassessment in 2001 much of his work had been attributed to Girolamo di Giovanni. The contribution made by Giovanni Angelo d'Antonio to the reputation of the Camerino school of the 15th century is now considered at least as significant as that made by Giovanni Boccati and Girolamo di Giovanni.
