Imogene Duncan was once a promising playwright who now works in a low-paying magazine job in New York City. After her affluent boyfriend leaves her and she is fired from her magazine gig, she stages a suicide attempt in an effort to get her ex's attention and is accidentally discovered by her friend Dara. Held in the hospital on a 5150, she is eventually released into her estranged mother's care where she is taken to her childhood home in New Jersey. Shortly after returning she hears a conversation between her mother and her new boyfriend, George Bousche, and learns that her father never died, but instead left the family to pursue a PhD. After learning that her father wrote a book, she goes to the local library and steals it. She discovers from the back cover that he lives in New York City and convinces her mother's boarder, Lee, to take her there, but is forced to return after she is barred access from her apartment and her friend, Dara, refuses to let her stay in her home. To pay Lee back for driving her to the city, Imogene goes to see him perform in his Backstreet Boys tribute band. Afterwards they talk about Imogene's failed career as a playwright. Years ago, after she won a prestigious grant, Imogene failed to write an actual play and now believes she cannot write. Lee accidentally discovered her old plays while living in her room and believes she is talented and should attempt to write again. They sleep together and the following morning she, Lee and her brother, Ralph, head back to the city to go to Dara's book launch party. The launch goes poorly as no one is particularly happy to see her. Her brother Ralph is nearly arrested and is brought to the party by the police. After they leave the party, Ralph takes them to their father's house where Ralph reveals that he knew his father was alive the entire time. Imogene and Ralph have dinner with their wealthy father and his new wife where he expresses no regret over his decision to leave them. After their father offers Imogene money to help fix her life she leaves him and returns home to her mother. After Imogene and her mother discuss her father an assassin arrives looking for Bousche and threatens to kill the family. He is prevented from doing so by Imogene, who dons her brother's human exo-skeleton suit and attacks him. Ultimately Imogene writes a play based on her experiences called Exo-life starring Julia Stiles, which receives a standing ovation.
On review aggregatorRotten Tomatoes, the film holds an approval rating of 22% based on 94 reviews, with an average rating of 4.44/10. The website's critics consensus reads: "Largely witless and disappointingly dull, Girl Most Likely strands the gifted Kristen Wiig in a blandly hollow foray into scattershot sitcom territory." On Metacritic, the film has a weighted average score of 38 out of 100, based on 33 critics, indicating "generally unfavorable reviews". Upon its festival release, Girl Most Likely garnered mixed reviews from critics. Christopher Schobert from film blog The Playlist called the film "a big-screen sitcom, elevated by Kristen Wiig and Annette Bening". He wrote that Wiig's "likability oozes from every scene in Shari Springer Berman and Robert Pulcini's occasionally winning, a touch too sitcom-y, but often very funny look at one woman’s offbeat family and her attempts at discovering just what went wrong on the road to success. It is not, to be sure, Bridesmaids-style humor, and never reaches that blockbuster’s belly laugh count. But the film doesn't lack for moments of inspired comedy, and I expect it to find an audience." Deborah Young, writing for The Hollywood Reporter, also felt that "the film’s great strength is its intuitive casting. The actors interact so well that it’s hard to single out one performance, though it’s perhaps Bening who wins the day for the sexy humanity she gives to the former go-go dancer Zelda. Morgan’s screenplay is full of intelligent dialogue that got real laughs from the audience on its Toronto bow." In his review, Justin Chang from Variety felt that "an able cast, led by Kristen Wiig’s prickly lead turn, saves this uneven, excessively quirky but ultimately ingratiating story Offering another sly snapshot of the filmmakers' native New York, a la The Nanny Diaries and The Extra Man this soft-bellied crowdpleaser should post modest numbers in specialty play and DVD/VOD rotation.
