Girolamo was the son of Antonio di Andrea and Lucia di Bernardo Balbi of the patrician class. His father belonged to the dalle Rose branch of the Donato family. His birth is usually given as around 1456 or before 1457. Giovanni degli Agostini places his birth in 1457, but also gives his age as 57 at his death. He is recorded as 18 years old when presented to the avogadori di Comun on 22 or 27 November 1474. He married Maria di Ludovico Gradenigo and passed his entire career in public service, for which reason he seems to have died poor. Donato learned Latin and Greek in childhood. His Greek tutor was Theodore Gaza. He studied philosophy and theology under Nicoletto Vernia at the University of Padua, receiving his degree of doctor of arts on 16 June 1478. He was studying law at Padua in 1489, when he held the office of rector jointly with Marco Dandolo. At Padua, Donato "was generally held to be one of the most learned of the Peripatetics who flourished in the city". His speech on the subject of the unmoved mover in the academic year 1480–81 inspired Elia del Medigo to compose his Quaestio de primo motore.
Public career
Donato's first public charge was as ambassador to the court of René II, Duke of Lorraine, in 1483. A string of ambassadorships followed: to the Republic of Genoa in 1484; to the Kingdom of Portugal in 1486; to Maximilian I, elected Holy Roman Emperor, in 1488; to the Duchy of Milan in 1489–90; and to the Holy See in 1491–92. In 1492, Donato was elected podestà and captain of Ravenna. In 1494–95, he served as one of the avogadori di Comun. Between 1495 and 1497, he was podestà and vice-captain of Brescia. There he hired the Albanian scholar Marino Becichemo as a tutor for his son Filippo. While still podestà of Brescia, he went on an embassy to the Republic of Lucca in 1496. During 1497–1499, he reprised his role as ambassador to the Holy See. Afterwards he was visdomino in the Duchy of Ferrara, but there is some disagreement concerning the dates of his visdominato: he appears to have been in Ferrara in July 1499, but other sources do not place him there until 1500 or even February 1501. In 1501, he returned as ambassador to the Emperor-elect Maximilian. Donato was one of the 41 electors in the election of the doge in 1501; Leonardo Loredan was elected. He served as ambassador to the Kingdom of France in 1501–02. In 1503–04, he was podestà of Cremona. In the latter year, he was elected to be one of the Savi del Consiglio. He was selected for the embassy of congratulation to newly elected Pope Julius II that, for political reasons related to the downfall of Cesare Borgia, did not set out until March 1505. Later that year he joined the Ducal Council. In 1506, he was appointed Duke of Crete. He wrote a letter describing the Cretan earthquake of 1508. His office ended in 1508 and in 1509 he rejoined the Ducal council. In April 1509, Venice was placed under interdict by Julius II and targeted by the forces of the League of Cambrai. Donato led the embassy that negotiated the lifting of the excommunication in February 1510. He continued on as ambassador to the Holy See, and when the League fell apart negotiated the creation of the Holy League allying Venice with the Holy See, Spain and England on 5 October 1511. He was proclaimed a hero in Venice. Already ill at the time, he died in Rome two weeks later. The Great Council awarded pensions to his widow and his nine surviving sons. According to Agostini, a Frenchman hearing of his death remarked, "He was a man of letters before he was a statesman; and he distinguished himself equally in both professions."