Giuseppina Vadalà fought together with her sister Paolina during the Siege of Messina, the revolt for Italian unification that took place in Messina on September 5, 1848. Messinese by birth, she was the daughter of the patriot Pietro Vadalà and wife of Orazio Nicosia, another fighter who joined the revolt against the Bourbons of Naples. Giuseppina had three children: Totò, Orazio, and Bianca. When her elder son Totò grew up, he decided to move to Naples, where he threw himself heart and soul into the cause of Italian unification. When her daughter Bianca was grown to womanhood, she married Giovanni Bovio, a noted philosopher and republican politician. The Italiangovernment awarded Vadalà the Silver Medal of Military Valor for her part in pro-unification battles during the years 1848–1849 and 1860.
According to the historical account that describes the tradition of the Messinese religious feast of Cristo Lungo in Castroreale, Giuseppina Vadalà moved to that municipality in 1854, because her husband Orazio Nicosia got a job there. Soon after they had arrived in Castroreale, Vadalà became ill with cholera due to a severe epidemic in Messina where she had contracted it. All her strength was ebbing away to the point of death. It was then that her husband went onto the balcony of their house and knelt in prayer before the statue there, which bore the image of crucified Jesus. Right after this occurrence Vadalà rallied and regained her health, and for the people of Castroreale it was a miracle. Orazio Nicosia donated twenty gold oncias for outfitting the statue. From that August 25 onward, the feast of the Crucified Jesus was consecrated in the town.
Later on, Giuseppina Vadalà emigrated to South America, to the country of Chile. She died on October 7, 1914 in Santiago de Chile. The historical accounts lament the lack of interest in honoring her shown by the municipality of Messina at her death. It was limited to a mention of her in the city bulletin for the month of November. On the other hand, in South America Vadalà had a procession with great funerary honors celebrated by the Italian community residing in Chile and with the presence of politicians and diplomats of the two countries. The eulogy was given by one Professor Noè, recalling her virtue and acts of valor. She was laid to rest in the Chilean mausoleum of the Italian Society.