Glibornuride


Glibornuride is an anti-diabetic drug from the group of sulfonylureas. It is manufactured by MEDA Pharma and sold in Switzerland under the brand name Glutril.

Synthesis

Gliburnide is an endo-endo derivative made from camphor-3-carboxamode by borohydride reduction, followed by Hofmann rearrangement to carbamate, followed by displacement with sodium tosylamide.