The globus pallidus also known as paleostriatum or dorsal pallidum, is a subcortical structure of the brain. It consists of two adjacent segments, one external, known in rodents simply as the globus pallidus, and one internal, known in rodents as the entopeduncular nucleus. It is part of the telencephalon, but retains close functional ties with the subthalamus in the diencephalon – both of which are part of the extrapyramidal motor system. The globus pallidus is a major component of the basal ganglia, with principal inputs from the striatum, and principal direct outputs to the thalamus and the substantia nigra. The latter is made up of similar neuronal elements, has similar afferents from the striatum, similar projections to the thalamus, and has a similar synaptology. Neither receives direct cortical afferents, and both receive substantial additional inputs from the intralaminar thalamus.
Structure
Pallidal nuclei are made up of the same neuronal components. In primates, almost all pallidal neurons are very large, parvalbumin-positive, with very large dendritic arborizations. These have the peculiarity of having the three-dimensional shape of flat discs, parallel to one another, parallel to the border of the pallidum. and perpendicular to the afferent striatopallidal axons. There are only a few small local circuitry neurons. The globus pallidus is traversed by the numerous myelinated axons of the striato-pallidonigral bundle that give it the pale appearance from which it is named. The ultrastructure is very peculiar, as the long dendrites are everywhere, without discontinuity, covered by synapses.
The globus pallidus is a structure in the brain involved in the regulation of voluntary movement. It is part of the basal ganglia, which, among many other things, regulate movements that occur on the subconscious level. If the globus pallidus is damaged, it can cause movement disorders, as its regulatory function will be impaired. There may be cases in which damage is deliberately induced, as in a procedure known as a pallidotomy, in which a lesion is created to reduce involuntary muscle tremors. When it comes to regulation of movement, the globus pallidus has a primarily inhibitory action that balances the excitatory action of the cerebellum. These two systems evolved to work in harmony with each other to allow smooth and controlled movements. Imbalances can result in tremors, jerks, and other movement problems, as seen in some people with progressive neurological disorders characterized by symptoms like tremors. The basal ganglia acts on a subconscious level, requiring no conscious effort to function. When someone makes a decision to engage in an activity such as petting a dog, for example, these structures help to regulate the movement to make it as smooth as possible, and to respond to sensory feedback. Likewise, the globus pallidus is involved in the constant subtle regulation of movement that allows people to walk and engage in a wide variety of other activities with a minimal level of disruption.
Pallidonigral pacemaker
The two pallidal nuclei and the two parts of the substantia nigra constitute a high-frequency autonomous pacemaker.
Common afferents
The two parts receive successively a large quantity of GABAergic axonal terminal arborisations from the striatum through the dense striato-pallidonigral bundle. The synaptology is very peculiar. The striatal afferents contribute more than 90% of synapses. The two pallidal nuclei receives dopaminergic axons from the pars compacta of the substantia nigra. , globus pallidus CAUDAL: subthalamic nucleus, substantia nigra rgic pathways that are excitatory on the direct pathway and inhibitory on the indirect pathway.
Pathway
This area of the basal ganglia receives input from another area, called the striatum, which has two parts, the caudate nucleus and the putamen. This data is routed to the thalamus, either directly or indirectly. In the case of the interna, one area of the globus pallidus, the structure can feed directly to the thalamus. The externa, which lies on the outside of this structure, feeds information to the interna, where it can be passed on to the thalamus.
History
The origin of the name is not established. It was known by Dejerine, but not by Santiago Ramón y Cajal. As the elements in no way have the shape of a globe, Foix and Nicolesco, the Vogts, Crosby et al. followed by the Terminologia anatomica proposed the simpler term of pallidum. For a long time the globus pallidus was linked to the putamen and termed the lentiform nucleus, a heterogeneous anatomical entity that is part of the striatum rather than the pallidum. The link with the substantia nigra pars reticulata was stressed very early on due to the similarities in dendritic arborisation but, in spite of strong evidence, this association remains controversial.
