Glycineamide ribonucleotide
Glycineamide ribonucleotide is an intermediate in de novo purine biosynthesis.
It is formed from phosphoribosylamine by the enzyme phosphoribosylamine—glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form phosphoribosyl-N-formylglycineamide.
GAR formation is stimulated by luteinizing hormone and chorionic gonadotropin via activation of Glc-6-P-dehydrogenaseSynonyms
Several names are associated with GAR:
- 5'-p-Ribosylglycinamide
- 5'-p-Ribosylglycineamide
- 5'-Phosphoribosyl-glycineamide
- 5'-Phosphoribosylglycinamide
- 5'-Phosphoribosylglycineamide
- Glycineamide ribotide
- Glycinamide ribonucleotide
- Glycineamide ribonucleotide
- N-glycinamide
- N-Glycyl-5-O-phosphono-D-ribofuranosylamine
- N1-glycinamide
