Grass sickness


Grass sickness, alternatively termed equine dysautonomia, is a rare but predominantly fatal illness in horses. Grass sickness may affect all types of horse, pony and donkey, and has affected some well known horses including the thoroughbred stallions Dubai Millennium, Moorestyle and Mister Baileys.

Clinical signs

Grass sickness is a polyneuropathy affecting the central, peripheral and enteric nervous systems. The majority of visible clinical signs are related to paralysis within the digestive tract although nerve damage occurs throughout the body. There are three forms of grass sickness:
Clinical signs common to all subsets include: depression, anorexia, colic, excess salivation, constipation, nasogastric fluid secretion, patchy sweating, muscle tremors and eyelid drooping.

Cause

The cause remains unknown, but the toxin produced from the bacterium Clostridium botulinum type C may be involved.
Clostridium botulinum is a soil-borne bacterium, which may be better known for producing clinical signs of botulism. It may cause grass sickness when the spores of C. botulinum type C are ingested and produce their toxin locally within the intestine.

Risk factors

The main risk factor for grass sickness, as the name may suggest, is grass. The disease is almost always seen in grazing animals, although there are isolated reports of the condition occurring in stabled horses. Grass sickness is most frequently seen in young horses aged between two and seven, and is particularly prevalent during April, May and June, and later in the autumn, after a spurt of grass growth.
Other risk factors which may increase the likelihood of a horse developing grass sickness include: soil disturbance, worming with ivermectin based dewormers, movement to new pasture, stress, and grazing on a field which has previously produced a case of grass sickness.

Diagnosis

Diagnosis of grass sickness in the live animal requires a thorough clinical examination including a rectal examination. Definitive diagnosis can only be made at surgery or at post-mortem. Differential diagnoses for grass sickness are varied and include any other cause of colic and weight loss, tying-up, laminitis, botulism, choke and dental problems.

Treatment

There is no treatment for grass sickness. A proportion of CGS cases survive following periods of intensive nursing. Overall, the mortality rate of equine grass sickness is over 95%.

History

The first cases of grass sickness were recorded in eastern Scotland in 1909.