The colonnade consists of three sections that were built separately over the course of the second and third century CE. The western stretch of the colonnade is the oldest and started at the West Gate near the Funerary Temple. The eastern section stretched from the Monumental Arch in the center of the town to the entrance of the Temple of Bel. The middle section was built last to connect the two separate colonnades. It met the western stretch at the Great Tetrapylon, and the eastern stretch at the Monumental Arch.
Western section
The western colonnade was the first section to be built. Inscriptions found on some columns confirm that works started before 158 CE. The straight avenue ran in northwest-southeast direction and stretched for, the longest of the three sectors. The main avenue's width was while the side streets were in width. The colonnade's western terminus, the West Gate, was built in the late second-century CE. The avenue also connected in a right angle to the Transverse Colonnade which stretched to the Damascus Gate in the south.
Eastern section
The eastern sector of the Great Colonnade started at the Monumental Arch and stretched in a northwest-southeast direction towards the propylaea of the Temple of Bel. Work on the colonnade started after the completion of the propylaea in 175 CE and continued through the beginning of the third-century CE. This section is the widest of the Great Colonnade with a uniform width of for the main street and for the sidewalks. A corner of the temenos of the Temple of Nebu was demolished to allow the colonnade an uninterrupted line of sight towards the Monumental Arch from the west and a wider access to the section leading to the Temple of Bel. A nymphaeum was later added to the eastern colonnade between the Bel and Nebu temples.
Middle section
The middle colonnade, stretching from east to west, was constructed to connect the two earlier colonnades. Work on the central avenue began from the Monumental Arch, where it met the eastern colonnade, sometime in the early third-century CE. The section stretched until the Great Tetrapylon where it met the western colonnade in an oval plaza. The central colonnade also incorporated the portico of the baths. The central section of the Great Colonnade became the most important with several civic buildings clustered around it, including the caesareum, the theatre, the baths and the Temple of Nebu. The width of the main street varies from at its widest near the tetrapylon, to when it reaches the Monumental Arch. The sidewalks also vary in width between for the northern sidewalk and for the southern one.
Architecture and significance
The colonnade's early columns, especially in the western stretch, were built using the classical opus emplectum building technique. The columns consisted of six to eight short sections. This technique was gradually replaced, from the 220s, by what historian Marek Barański termed opus Palmyrenum. The newer technique, seen in the middle and eastern stretches of the colonnade, utilized three long segments instead of the short drums. The technique allowed for significantly faster construction at the time. The Corinthian columns were fitted with decorated brackets that bore dedicatory inscriptions. The brackets were used to hold bronze statues of important figures. Dedicatory inscriptions to Zenobia and Odaenathus dating to between 257 and 267 were discovered on columns set up in front of the theatre.