Hofmo started her literary career submitting poems for publication to a wide variety of presses, including the communist newspaper Friheten and weekly magazines such as Hjemmet. One of her first published poems was dedicated to her close friend and Jewish refugeeRuth Maier. It was published in Magasinet for Alle, opening with the lines: Ruth Maier was an Austrian native who had found refuge in Norway in 1939. During the Occupation of Norway by Nazi Germany, Maier was arrested by German officials in Norway during 1942. She was deported and murdered during the Holocaust at Auschwitz. This event became by all accounts the central tragedy in Hofmo's life. She was hospitalized in 1943 for depression, starting a lifelong struggle with mental illness. Following the liberation of Norway in 1945, Hofmo traveled extensively. She was in Paris in the autumn of 1947 and in Brittany in the spring of 1950. She also made several trips to Copenhagen and also traveled to Stockholm, Amsterdam and London. She also wrote essays for publication, primarily in the daily newspaperDagbladet. The topics included travel, Nordic poetry, and philosophical topics. Among her most noted contributions are a lengthy debate on the minimal daily cost of living a life barely out of penury in Paris and a treatise in defense of her poet colleague Olav Kaste. In 1953, she stopped publishing essays and instead concentrated on her poetry. Dagbladet published seven of her poems between 1952 and 1956. She published five poetry collections between 1946 and 1955. She was institutionalized at Gaustad Hospital, suffering from mental illness, characterized as schizophrenia, paranoid type, from 1955 to 1971, leading to what was known as her "16 years of silence." Following her discharge, she went into a period of considerable productivity, publishing fifteen poetry collections between 1971 and 1994. From 1977 to her death she never left her apartment in the Nordstrandsection of Oslo.
Personal life
Although Gunvor Hofmo and Ruth Maier both characterized their relationship as unusually close and intimate, there is no indication that it was romantic or sexual. In 1947, Hofmo moved in with another writer, Astrid Tollefsen became one of the first Norwegians living in an openly lesbian relationship. They continued to live and travel together until Hofmo was incapacitated and committed for her mental illness.