HLA-DR2


HLA-DR2 of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

Serology

Disease associations

DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis, and narcolepsy, tuberculoid leprosy, ulcerative colitis, primary biliary cirrhosis and autoimmune hepatitis. DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetase and chronic interstitial lung disease.

Genetic linkage

DR2 is linked to the HLA-DR51.