HNF1B


HNF1 homeobox B, also known as HNF1B or transcription factor 2, is a human gene.

Function

TCF2 encodes transcription factor 2, a protein of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Deficiency of TCF2 cause abnormal maternal-Zygote transition and early embryogenesis failure.Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5. A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.