HR (gene)


Protein hairless is a protein that in humans is encoded by the HR gene.
This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases.

Human Genetics

Variations in this gene are involved in low levels of hair Mutations in this gene in humans have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.
The protein contains a Zinc finger domain.