Dr. Reese was recruited to the University of Wisconsin by Dr. William Lorenz in 1924. Together with Dr. William Bleckwenn, Reese and Lorenz comprised the professional staff of the Wisconsin Psychiatric Institute and the Department of Neuropsychiatry at the University of Wisconsin School of Medicine. Dr. Reese developed a particular interest in neurosyphilis, which, in the 1920s and 1930s, accounted for >10% of all psychiatric illnesses. In the days before effective antibiotic therapy of that disease, somewhat unconventional treatments were utilized. One of them involved the purposeful infection of patients with malarial organisms, with the goal of creating a fever. That technique followed the empiric observation that syphilis sometimes improved after febrile illnesses. Reese collaborated with investigators at other institutions using this approach, known as the "Wagner-Jauregg" treatment. Lorenz and Bleckwenn also focused on neurosyphilis with respect to their research endeavors, and, as the preeminent neurologist of the group, Reese was asked to evaluate the side-effects of experimental antisyphilitic drugs on nervous system function. The trio of physicians at Wisconsin went on to publish more than 100 papers on neurosyphilis; in particular, they developed and refined an alternative to Wagner-Jauregg therapy, using an arsenical medication called tryparsamide. Until the advent of penicillin in the 1940s, it was probably the most effective treatment for neurosyphilis available. Reese had several other research interests in neuropsychiatry as well. These included multiple sclerosis, porphyria, schizophrenia, idiopathic myopathies, and myositis. Reese was widely sought-after as a consultant in neurology at UW, especially after the departure of Dr. Bleckwenn from Madison for health reasons in 1954. Hans was devoted to both his colleagues and patients, and that feeling was warmly reciprocated. In 1955, a new dean, Dr. John Zimmerman Bowers, was appointed at the UW medical school. His principal interest became the systematic replacement of existing medical school department chairpersons with external appointees from other institutions, in the belief that professional "inbreeding" at the school had been detrimental to its academic growth. Despite Dr. Reese's accomplishments and reputation, including past presidency of the American Neurological Association he was summarily ousted by Bowers as chairman of Neuropsychiatry in 1956. Reese had a myocardial infarct shortly after being dismissed. Nonetheless, following his recovery, he remained on the UW faculty and continued his academic contributions until the end of his life.
During the second world war, Reese was asked by the U.S. government to essentially act as a spy in Europe, to gather data on new weapons being developed by the Nazis. As a native speaker of German and a person well-educated in the sciences, he was ideal for that role. Hans accepted the challenge, and provided valuable information to the War Department upon his return to the U.S. in 1944.
Death
Hans Reese died of another myocardial infarct in June 1973, at age 81. He is buried in Madison and was survived by his wife, Theresa, and their daughter, Sybil.