This commando was initially sent to occupy mountain passes of the Drakensberg between the Orange Free State and the British Colony of Natal. English speakers of Harrismith were sent to the Oliviershoek Pass or serve in the Town Guard. The first engagement of the war was at Besters Station with an advance on Ladysmith when this commando occupied Middle Hill. 100 men from the commando were part of the initial assault. The first Free Stater to die in the Anglo Boer War, Fred Johnson, came from this commando. This Commando was also involved in the battle of Rietfontein which took place on 24 October 1899 between six commandos of the Free State Army commanded by General A Piet Cronje and a British Flying Column dispatched from Ladysmith under the command of Sir George White. The Free State forces consisted of the following commandos:
In 1900, the commando together with those from Vrede and Heilbron were again assigned the defence of the mountain passes. The remnants of the Harrismith Commando was captured in a sweep operation between block house lines by a British column on 13 February 1902.
With the UDF
By 1902 all Commando remnants were under British military control and disarmed. By 1912, previous Commando members could however join shooting associations. By 1940, such commandos were under control of the National Reserve of Volunteers. These commandos were formally reactivated by 1948.
With the SADF
During this era, the unit was mainly used for rural area force protection, police assistance and stock theft control. The unit was also engaged in securing the Lesotho border. The unit resorted under the command of the SADF's Group 25.
On 11 June 2017, a Reconciliation Memorial was unveiled at Platrand near Ladysmith. This memorial honours the fierce battle that occurred on 6 January 1900 between the Devonshire Regiment and the Harrismith Commando on that site.
Market Square
The towns market square has a monument, adjacent Warden Street, to the memory of those who served in the Harrismith Commando. An obelisk in the same street in front of the Dutch Reformed Church lists the names of the men of the Harrismith Commando who died in the Anglo Boer war. Of the 73 names, 19 are listed as having died at Platrand, 32 killed or mortally wounded elsewhere and 22 who died in prisoner of war camps overseas and buried in India and Sri Lanka.