Homeostatic model assessment
The homeostatic model assessment is a method used to quantify insulin resistance and beta-cell function. It was first described under the name HOMA by Matthews et al. in 1985.Derivation
The HOMA authors used data from physiological studies to develop mathematical equations describing glucose regulation as a feedback loop.
They published computer software that solves the equations, so that insulin resistance and β-cell function can be estimated from fasting glucose and insulin levels. They also published an equation that gave approximately the same answers as an early version of the computer software.
The computer model has since been improved to a HOMA2 model to better reflect human physiology and recalibrated to modern insulin assays. In this updated version it is possible to determine insulin sensitivity and β-cell function from paired fasting plasma glucose and radioimmunoassay insulin, specific insulin, or C-peptide concentrations. The authors recommend the computer software be used wherever possible.
