IκBα
IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.The gene encoding the IκBα protein is mutated in some Hodgkin's lymphoma cells; such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.Interactions
IκBα has been shown to interact with:
- BTRC,
- C22orf25,
- CHUK,
- DYNLL1,
- G3BP2,
- Heterogeneous nuclear ribonucleoprotein A1,
- IKK2,
- NFKB1,
- P53,
- RELA,
- RPS6KA1,
- SUMO4, and
- Valosin-containing protein.
