IGK@
Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa light chains of antibodies.
In humans the κ chain is coded for by V, J and C genes in this region. These genes undergo VJ recombination to generate a diverse repertoire of immunoglobulins.Genes
The immunoglobulin kappa locus contains the following genes:
- IGKC: immunoglobulin kappa constant
- IGKJ@: immunoglobulin kappa joining group
- * IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5
- IGKV@: immunoglobulin kappa variable group
- * IGKV1-5, IGKV1-6, IGKV1-8, IGKV1-9, IGKV1-12, IGKV1-16, IGKV1-17, IGKV1-27, IGKV1-33
- * IGKV1D-8, IGKV1D-12, IGKV1D-13, IGKV1D-16, IGKV1D-17, IGKV1D-22, IGKV1D-27, IGKV1D-32, IGKV1D-33, IGKV1D-39, IGKV1D-43
- * IGKV2-24, IGKV2-28, IGKV2-30, IGKV2-40
- * IGKV2D-26, IGKV2D-28, IGKV2D-29, IGKV2D-30, IGKV2D-40
- * IGKV3-11, IGKV3-15, IGKV3-20
- * IGKV3D-7, IGKV3D-11, IGKV3D-20
- * IGKV4-1
- * IGKV5-2
- and a number of non-functional and pseudogenes
