IL18RAP
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b, is a human gene.Function
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1, a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 in response to IL18.Variants at IL18RAP have been linked to susceptibility to Coeliac disease.
