Indium-111


Indium-111 is a radioactive isotope of indium. It decays by electron capture to cadmium-111 with a half-life of 2.8 days.
111In chloride solution is produced by proton irradiation of a cadmium isotope OR in a cyclotron, as recommended by International Atomic Energy Agency. The former method is more commonly used as it results in a high level of radionuclide purity. 111In has a half-life of 2.81 days decaying by electron capture to 111Cd, which is stable.
It is commonly used in Nuclear Medicine Diagnostic Imaging by radio-labeling targeted molecules or cells. During its radioactive decay, it emits low energy gamma photons which can be imaged using planar or SPECT gamma cameras of 171.3 keV and 245.4 keV

Uses in nuclear medicine

When formulated as an 111In Cl solution, it can be used to bind antibodies or other molecular targeted proteins or other molecules, typically using a chelate to bind the radionuclide to the targeting molecule during the radiosynthesis/ radiolabeling process, which is tailored to the desired product.

111In labeled [antibodies]

111In can also be formulated in the chemical form 111In oxyquinoline for labeling blood cells and components