Infectious Diseases Society of America
The Infectious Diseases Society of America is a medical association representing physicians, scientists and other health care professionals who specialize in infectious diseases. It was founded in 1963 and is based in Arlington, Virginia. As of 2018 IDSA had more than 11,000 members from across the United States and nearly 100 other countries on six different continents. IDSA's purpose is to improve the health of individuals, communities, and society by promoting excellence in patient care, education, research, public health, and prevention relating to infectious diseases. It is a 501 organization.
History
The IDSA was formed from two different groups. Jay P. Sanford and a group that included members of the American Federation for Clinical Research, American Society for Clinical Investigation, and the Association of American Physicians, met annually in the Spring in Atlantic City, New Jersey to discuss infectious disease topics. There was a call to formalize the meetings between the two groups.Henry Welch, PhD, sponsored a group that met in the Fall in Washington, D.C., formed out of the American Society for Microbiology, that discussed aspects of infectious diseases and proposed a new dinner group to discuss topics related to infectious diseases. In 1962, Maxwell Finland, MD, sponsored this group. Finland approached John E. Blair, president of ASM, who expressed interest in forming an infectious diseases division within the ASM. Finland formed a planning committee. Lowell A. Rantz, MD, chaired the committee with Edward H. Kass, MS, PhD, MD, as the secretary. The committee decided to create an organization independent of ASM.
On October 26 and 27, 1963, the committee met in Warrenton, VA with 125 charter members and guests. Rantz was elected as president, but he nominated Finland to be the first instead and Kass as secretary and treasurer. Edward C. Curnen, MD, Mark H. Lepper, MD, Samuel P. Martin, MD, David E. Rogers, MD, Monroe J. Romansky, MD, and Alex J. Steigman, MD, were the first councilors and the IDSA was born.
in 2018, IDSA put out a statement about antibiotic research. Low financial returns on antibiotic research has caused stock prices to go down, and companies have abandoned antibiotic research and development. In turn, this has put pressure on the few remaining companies to deliver new antibiotics. iDSA proposed that the government create incentives that reward and support private sector work toward a "robust, renewable antibiotic supply."
Support for the Prevention and Public Health Fund
On November 3, 2017, the U.S. House passed a bill, H.R. 3922 that cuts $6.35 billion from the Prevention and Public Health Fund. Paul Auwaerter, president of IDSA, said that the cut would hurt both public health and national security. The PPHF fund comprises over 12 percent of the budget of the Centers for Disease Control and Prevention. Auwaerter said, "…a significant cut to the fund will have a very troubling impact on CDC efforts to prevent infections and respond to outbreaks in communities and health care settings."The PPHF was created under the Affordable Care Act to fund programs for prevention and public health activities. The fund supports programs that prevent, monitor, and respond to infectious diseases, including immunization programs; responses to outbreaks of "vaccine-preventable illnesses"; adult immunization registries; managing emerging health issues such as food-borne infection outbreaks and waterborne diseases; and programs that support Alzheimer's, diabetes, heart disease, and stroke prevention strategies.
Several organizations such as the American Heart Association and American Lung Association joined the IDSA in opposing the cuts.
Publications and activities
IDSA publishes the following medical journals:- Clinical Infectious Diseases
- Journal of Infectious Diseases
- Open Forum Infectious Diseases
Antimicrobial Resistance (10 x '20) Initiative
The World Health Organization has identified antimicrobial resistance as one of the three greatest threats to human health. IDSA has identified antimicrobial resistance as a priority for the organization.In 2010, IDSA launched the 10 x '20 Initiative, which seeks a global commitment to create an antibiotic research and development enterprise powerful enough to produce 10 new systemic antibiotics by the year 2020. The initiative was launched as a response to the growing problem of antibiotic resistance and the lack of development of new antibiotics.
According to IDSA, new antibiotic development has slowed to a standstill due to market failure and regulatory disincentives. Antibiotics aren't as profitable as other drugs. Also, the U.S. Food and Drug Administration has long delayed publishing workable guidance describing how companies should design antibiotic clinical trials. Moreover, once a new antibiotic makes it to market, physicians hold it in reserve for only the worst cases rather than rushing to use it on all their patients due to fear of drug resistance. These economic and regulatory disincentives have made it far too difficult for companies to continue developing new antibiotics. It is estimated that the cost to the U.S. health care system of antibiotic resistant infections is $21 billion to $34 billion each year and more than 8 million additional hospital days.
On May 1, 2011, IDSA published a policy paper titled "Combating Antimicrobial Resistance: Policy Recommendations to Save Lives" in Clinical Infectious Diseases. The paper detailed the organization's recommendations for specific public policy strategies and research activities needed to promote the best interests of patients and health care professionals. Specifically, the paper urged creation of incentives to support antibiotic research and development; new rapid diagnostic tests to more quickly diagnose patients; greater coordination of government agencies to support surveillance, data collection, research, and prevention and control; and aggressive promotion of the judicious use of currently available antibiotics. IDSA's policy paper also proposed the creation of an Antimicrobial Innovation and Conservation Fee that would help pay for antibiotic R&D and stewardship efforts necessary to make progress against antibiotic resistance.
Throughout 2012, IDSA garnered support of several medical organizations and pharmaceutical companies for a new FDA approval pathway, called the Limited Population Antibacterial Drug mechanism, to address an unmet medical need by speeding up development of antibiotics to treat patients who have serious infections for which therapeutic options are insufficient. The LPAD mechanism would allow for testing a drug's safety and effectiveness in smaller, shorter, and less expensive clinical trials, similar to the Orphan Drug Program.
In addition to the 10 x '20 Initiative, IDSA supports legislative and administrative efforts to strengthen the U.S. response to antimicrobial resistance, such as enhanced coordination and leadership, surveillance, prevention and control, and research efforts. IDSA also promotes the establishment of antimicrobial stewardship programs and integration of good stewardship practices in every health care facility across the United States and is working to eliminate inappropriate uses of antibiotics in food, animals and other aspects of agriculture.
In a followed up policy report released on April 17, 2013, titled "10 X '20 Progress – Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America", IDSA expressed grave concern over the weak pipeline of antibiotics to combat the growing ability of bacteria, especially the Gram-negative bacilli, to develop resistance to antibiotics. Since 2009, only 2 new antibiotics were approved in United States, and the number of new antibiotics annually approved for marketing continues to decline. The report could identify only seven antibiotics currently in phase 2 or phase 3 clinical trials to treat the GNB which includes E. coli, Salmonella, Shigella and the Enterobacteriaceae bacteria, and these drugs do not address the entire spectrum of the resistance developed by those bacteria. Some of these seven new antibiotics are combination of existent antibiotics. There are positive signs that the governments and health authorities in US and Europe have recognized the urgency of the situation. Collaborations are formed between the regulatory bodies and pharmaceutical industry with funding and added incentives. The IDSA's prognosis for sustainable R&D infrastructure for antibiotics development will depend upon clarification of FDA regulatory clinical trial guidance which would facilitate the speedy approval of new drugs, and the appropriate economic incentives for the pharmaceuticals companies to invest in this endeavor.
Lyme disease treatment guidelines
The IDSA recommends against long-term antibiotic treatment for Lyme disease, arguing that it is ineffective and potentially harmful. The American Academy of Neurology and National Institutes of Health similarly recommend against such treatment. However, a minority view holds that chronic Lyme disease is responsible for a range of medically unexplained symptoms, sometimes in people without any evidence of past infection. Groups of patients, patient advocates, and physicians who support the concept of chronic Lyme disease have organized to lobby for recognition of this diagnosis, as well as to argue for insurance coverage of long-term antibiotic therapy. Such groups have been critical of the IDSA guidelines on Lyme disease. Both sides of the argument were outlined in the 2008 American documentary film Under Our Skin.In 2006, Connecticut Attorney General Richard Blumenthal announced an antitrust investigation against the IDSA, accusing the IDSA Lyme disease panel of undisclosed conflicts of interest and of unduly dismissing alternative therapies and "chronic" Lyme disease. Blumenthal's investigation was closed on May 1, 2008 without charges when the IDSA agreed to submit its guidelines for review by a panel of independent scientists and physicians. Views on the motivation and outcome of the investigation varied. Blumenthal's press release described the agreement as a vindication of his investigation and repeated his conflict-of-interest allegations. The IDSA pointed to the closure of the investigation without charges, and the fact that the medical validity of the IDSA guidelines was not challenged. The IDSA cited mounting legal costs and the difficulty of presenting scientific arguments in a legal setting as their rationale for accepting the settlement.
A Forbes piece described Blumenthal's investigation as "intimidation" of scientists by Blumenthal, an elected official with close ties to Lyme advocacy groups.
The Journal of the American Medical Association described Blumenthal's investigation of the IDSA as an example of the "politicization of health policy" against the weight of scientific evidence, and voiced concern over a chilling effect on future decisions by medical associations.
Pursuant to their agreement with Blumenthal the IDSA guidelines were reviewed by an independent panel subject to strict conflict-of-interest guidelines and vetted by a medical ethicist. The panel supported the original IDSA guidelines, finding that "chronic Lyme disease" and "post Lyme syndrome" lack clear definitions and convincing biological evidence. Further, the report emphasized that several prospective clinical trials of prolonged antibiotic therapy for persistently symptomatic patients uniformly showed evidence of harm without convincing evidence of benefit.