Interleukin-23 receptor
Interleukin-23 receptor is a type I cytokine receptor. IL23R is the name of its human gene.Function
The protein encoded by this gene is a subunit of the receptor for IL-23. This protein pairs with the receptor molecule IL-12Rβ1, together forming the IL-23 receptor complex, and both are required for IL-23 signaling. This protein associates constitutively with Janus kinase 2, and also binds to transcription activator STAT3 in a ligand-dependent manner.Structure
Crystal structure of human IL-23R in complex with its cognate cytokine ligand IL-23.Clinical significance
Three variants in the IL23R gene have been shown to protect against Crohn's disease and ulcerative colitis.
The effect of IL-23R variations present in the population have been studied with an in vitro expression model system.Model organisms
s have been used in the study of IL23R function. A conditional knockout mouse line called Il23rtm2aWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
