I-40 enters Arkansas from Oklahoma at Dora in Crawford County. It heads east into Van Buren, giving access to Fort Smith as well across the Arkansas River to the south. Access is primarily via Interstate 540/US 71, which was built as a southern spur to Fort Smith in the 1970s. I-40 overlaps with US 71, forming a concurrency until the alignment of Interstate 49 breaks north to Fayetteville, Springdale, Rogers, Bentonville, and its northern Arkansas terminus in Bella Vista, with US 71 breaking away shortly afterwards at another interchange. The route continues to parallel US 64 into the Ozark Mountains by entering Franklin County and providing access to the Pig Trail Scenic Byway in Ozark. Interstate 40 runs through Clarksville, passes over part of Lake Dardanelle, and meets Highway 7 in Russellville. I 40 continues to the east through Morrilton before turning south to Conway and Faulkner County. In Conway, I-40 forms a concurrency with US 65 at exit 125, which will continue until exit 153a in Little Rock. The highway also has another junction with US 64 and US 65 Business in Conway before passing Lake Conway and entering the Little Rock metropolitan area.
Little Rock to Tennessee
Now in Pulaski County, I-40 heads towards the south-southeast as it heads to the town of Maumelle. It continues towards this direction until it reaches Interstate 430, which provides access along the western side of Little Rock. Further southeast near the Arkansas River, the route has a high volume interchange as the northern terminus of Interstate 30 as well as concurrent routes with US 67/US 167; US 65 turns south at this intersection, breaking the concurrency formed in Conway. I-40 continues east for before the US 67/US 167 concurrency turns north as a separate northeasterly expressway. From this point onward, Interstate 40 begins to parallel US 70 rather than US 64, which was a more or less a parallel route until Conway. The interstate continues to the east to intersect the concurrency of I-440/AR 440 before entering Lonoke County. Passing through Lonoke, the route runs through rural Arkansas with straight alignments and relatively few junctions, forming an overlap with US 63 in Hazen and meeting US 49/AR 17 in Brinkley. Upon entering St. Francis County, Interstate 40 runs northeast to Forrest City, where it intersects with Highway 1. Continuing northeast, I-40 enters Crittenden County, where it intersects with US 79 at Shearerville and enters West Memphis. The highway continues to the northeast to an interchange with Interstate 55, which form a concurrency east for. I-40 continues east onto the Hernando De Soto Bridge over the Mississippi River. The Tennessee border is at the midpoint of the river, and Memphis, Tennessee begins at the east side of the bridge.