Intrauterine growth restriction
Intrauterine growth restriction refers to poor growth of a fetus while in the mother's womb during pregnancy. The causes can be many, but most often involve poor maternal nutrition or lack of adequate oxygen supply to the fetus.
At least 60% of the 4 million neonatal deaths that occur worldwide every year are associated with low birth weight, caused by intrauterine growth restriction, preterm delivery, and genetic abnormalities, demonstrating that under-nutrition is already a leading health problem at birth.
Intrauterine growth restriction can result in a baby being small for gestational age, which is most commonly defined as a weight below the 10th percentile for the gestational age. At the end of pregnancy, it can result in a low birth weight.
Types
There are 2 major categories of IUGR: pseudo IUGR and True IUGRWith pseudo IUGR, the fetus has birth weight below tenth centiles needed in average for the corresponding GA but have normal ponderal index, subcutaneous fat deposition, body proportion.Here IUGR occurred due to uneventful intra uterine course and can be rectified by proper postnatal care and nutrition. Such babies are also called as small baby for the gestational age.
True IUGR:here IUGR occurred due to pathological conditions which may be either fetal or maternal in origin. In addition to low body weight they have abnormal ponderal index, body disproportion, low subcutaneous fat deposition. It is of two types, symmetrical and asymmetrical. Some conditions are associated with both symmetrical and asymmetrical growth restriction.
Asymmetrical
In asymmetrical IUGR, there is restriction of weight followed by length. The head continues to grow at normal or near-normal rates. A lack of subcutaneous fat leads to a thin and small body out of proportion with the liver. Normally at birth the brain of the fetus is 3 times the weight of its liver. In IUGR, it becomes 5-6 times. In these cases, the embryo/fetus has grown normally for the first two trimesters but encounters difficulties in the third, sometimes secondary to complications such as pre-eclampsia. Other symptoms than the disproportion include dry, peeling skin and an overly-thin umbilical cord. The baby is at increased risk of hypoxia and hypoglycaemia. This type of IUGR is most commonly caused by extrinsic factors that affect the fetus at later gestational ages. Specific causes include:- Chronic high blood pressure
- Severe malnutrition
- Genetic mutations, Ehlers–Danlos syndrome
Symmetrical
- Early intrauterine infections, such as cytomegalovirus, rubella or toxoplasmosis
- Chromosomal abnormalities
- Anemia
- Maternal substance abuse
Causes
Maternal
- pre-pregnancy weight and nutritional status
- poor weight gain during pregnancy
- poor nutrition
- anemia
- alcohol and/or drug use
- maternal smoking
- recent pregnancy
- pre-gestational diabetes
- gestational diabetes
- pulmonary disease
- cardiovascular disease
- renal disease
- hypertension
- celiac disease increases the risk of intrauterine growth restriction by an odds ratio of approximately 2.48
- blood clotting disorder/disease
Uteroplacental
- preeclampsia
- multiple gestation
- uterine malformations
- Placental insufficiency
Fetal
- chromosomal abnormalities
- Vertically transmitted infections
- Erythroblastosis fetalis
- Congenital abnormalities
Pathophysiology
If the cause of IUGR is intrinsic to the fetus, growth is restricted due to genetic factors or as a sequela of infection.
IUGR is associated with a wide range of short- and long-term neurodevelopmental disorders
Cerebral changes
effects – In postpartum studies of infants, it was shown that there was a decrease of the fractal dimension of the white matter in IUGR infants at one year corrected age. This was compared to at term and preterm infants at one year adjusted corrected age.grey matter effects – Grey matter was also shown to be decreased in infants with IUGR at one year corrected age.
Neural circuitry
Children with IUGR are often found to exhibit brain reorganization including neural circuitry. Reorganization has been linked to learning and memory differences between children born at term and those born with IUGR.Studies have shown that children born with IUGR had lower IQ. They also exhibit other deficits that point to dysfunction.
IUGR infants with brain-sparing show accelerated maturation of the hippocampus which is responsible for memory. This accelerated maturation can often lead to uncharacteristic development that may compromise other networks and lead to memory and learning deficiencies.
Management
has not been found to improve outcomes and therefore is not typically recommended.Mothers whose fetus is diagnosed with intrauterine growth restriction by ultrasound can use management strategies based on monitoring and delivery methods. One of these monitoring techniques is an umbilical artery Doppler. This method has been shown to decrease risk of morbidity and mortality before and after parturition among IUGR patients.
Time of delivery is also a management strategy and is based on parameters collected from the umbilical artery doppler. Some of these include: pulsatility index, resistance index, and end-diastolic velocities, which are measurements of the fetal circulation.
L-arginine has tentative evidence of benefit in reducing intrauterine growth restriction.
Outcomes
By definition, IUGR affects 10% of pregnancies, however when corrected for several factors such as low maternal weight it is estimated only around 3% of pregnancies are affected by true IUGR. 20% of stillborn infants have IUGR. Perinatal mortality rates are 4-8 times higher for infants with IUGR, and morbidity is present in 50% of surviving infants.According to the theory of thrifty phenotype, intrauterine growth restriction triggers epigenetic responses in the fetus that are otherwise activated in times of chronic food shortage. If the offspring actually develops in an environment rich in food it may be more prone to metabolic disorders, such as obesity and type II diabetes.
Sheep
In sheep, intrauterine growth restriction can be caused by heat stress in early to mid pregnancy. The effect is attributed to reduced placental development causing reduced fetal growth. Hormonal effects appear implicated in the reduced placental development. Although early reduction of placental development is not accompanied by concurrent reduction of fetal growth; it tends to limit fetal growth later in gestation. Normally, ovine placental mass increases until about day 70 of gestation, but high demand on the placenta for fetal growth occurs later.In adolescent ewes, overfeeding during pregnancy can also cause intrauterine growth restriction, by altering nutrient partitioning between dam and conceptus. Fetal growth restriction in adolescent ewes overnourished during early to mid pregnancy is not avoided by switching to lower nutrient intake after day 90 of gestation; whereas such switching at day 50 does result in greater placental growth and enhanced pregnancy outcome. Practical implications include the importance of estimating a threshold for "overnutrition" in management of pregnant ewe hoggets. In a study of Romney and Coopworth ewe hoggets bred to Perendale rams, feeding to approximate a conceptus-free live mass gain of 0.15 kg/day, commencing 13 days after the midpoint of a synchronized breeding period, yielded no reduction in lamb birth mass, where compared with feeding treatments yielding conceptus-free live mass gains of about 0 and 0.075 kg/day.
In both of the above models of IUGR in sheep, the absolute magnitude of uterine blood flow is reduced. Evidence of substantial reduction of placental glucose transport capacity has been observed in pregnant ewes that had been heat-stressed during placental development.