The first contact between Italy and Mexico was in 1869, just before the end of Italian unification in 1870; when Italy expressed its desire to open a consulate in Mexico. An Italian consulate was opened in Mexico in December 1872, however, diplomatic relations between the two nations were not established until 15 December 1874. In 1875, Mexico opened a diplomatic office in Rome. During World War I, Mexico remained neutral because it was involved in its own revolution during the same time and closed its diplomatic office in Rome. It re-opened its diplomatic office in 1922. In the 1930s, diplomatic relations between the two nations began to deteriorate when Italian Prime MinisterBenito Mussolini invaded and annexed Abyssinia during the Second Italo-Ethiopian War in 1935-1936. Mexico was one of the few countries to vehemently oppose the occupation of Abyssinia by Italian forces. During World War II, on 22 May 1942, Mexico declared war on the Axis powers due to German U-boat attacks on two Mexican oil tankers in the Gulf of Mexico that same year. Diplomatic relations were re-established on 1 June 1946 and Italy and Mexico signed a Treaty of Peace on 10 February 1947. In 1974, President Luis Echeverría Álvarez became the first Mexican head-of-state to visit Italy. In 1981, President Sandro Pertini became the first Italian head-of-state to visit Mexico. Since the initial visits, there have been numerous visits between leaders of both nations. Both nations have signed several bilateral agreements and have worked closely on several projects. In 2014, the Mexican Agency of International Cooperation for Development and the Italian Ministry of Foreign Affairs and International Cooperation have collaborated in funding and coordinating 12 research projects in strategic sectors, such as exact sciences, biomedical sciences, environment and energy, agriculture and agri-food, aerospace and technologies applied to cultural goods. On 17 October 2017, the V Meeting of the Mexico-Italy Binational Commission was held in Rome, headed by the Mexican Secretary of Foreign Affairs, Luis Videgaray and the Italian Minister of Foreign AffairsAngelino Alfano.
Both nations have signed numerous bilateral agreements such as Treaty of General Compulsory Arbitration ; Agreement in the Recognition of Consular Marriages Celebrated and Administered in both Nations Diplomatic Missions ; Agreement of Cultural Exchanges ; Agreement on Air Transportation ; Agreement on Technical Cooperation ; Agreement on Tourism Cooperation ; Agreement on the Avoidance of Double-Taxation and Tax Evasion ; Agreement of Cooperation in the Fight against the Misuse and Illicit Trafficking in Narcotic Drugs and Psychotropic Substances ; Agreement in Scientific and Technological Cooperation ; Agreement in the Promotion and Reciprocal Protection of Investments ; Agreement of Cooperation in Combating Organized Crime ; Agreement on Mutual Administrative Assistance in Customs Matters ; Extradition Treaty and a Treaty in the Assistance in Criminal Legal Matters.
In 1997, Mexico signed a Free Trade Agreement with the European Union. In 2018, two-way trade between both nations amounted to US$8.3 billion. Italy's main exports to Mexico include: pharmaceutical products; nuclear reactors; boilers; machines, apparatus and mechanical devices; and precious metals. Mexico's main exports to Italy include: vehicles; crude oil; lead minerals and their concentrates; and ethylene polyterephthalate. Italy is Mexico's ninth biggest trading partner globally. Mexico is Italy's second biggest trading partner in Latin-America. Over 400 Italian multinational companies such as Alfa Romeo, Enel Green Power, Eni, Fiat Automobiles, and Pirelli operate in Mexico. Mexican multinational companies such as Grupo Bimbo and Mexichem operate in Italy.