In 1875, Michurin leased a strip of land of about 500 square metres not far from Tambov, began collecting plants, and started his research in pomology and selection. In 1899, he acquired a much bigger strip of land of about 130,000 square metres and moved all of his plants there. In 1920, right after the end of the Russian Civil War, Vladimir Lenin ordered People's Commissar of AgricultureSemion Sereda to organize an analytic research project on Michurin's works and practical achievements. On September 11, 1922, Mikhail Kalinin visited Michurin at Lenin's personal request. On November 20, 1923, the Council of People's Commissars recognized Michurin's "fruit garden" as an institution of state importance. In 1928, the Soviets established a selectionist genetic station on the basis of Michurin's garden, which would be re-organized into the Michurin Central Genetic Laboratory in 1934. Michurin made a major contribution in the development of genetics, especially in the field of pomology. In his cytogeneticlaboratory, he researched cell structure and experimented with artificial polyploidy. Michurin studied the aspects of heredity in connection with the natural course of ontogenesis and external influence, creating a whole new concept of predominance. He proved that predominance depends on heredity, ontogenesis, and phylogenesis of the initial cell structure and also on individual features of hybrids and conditions of cultivation. In his works, Michurin assumed a possibility of changing genotype under external influence. Michurin was one of the founding fathers of scientific agricultural selection. He worked on hybridization of plants of similar and different origins, cultivating methods in connection with the natural course of ontogenesis, directing the process of predominance, evaluation and selection of seedlings, and acceleration of the process of selection with the help of physical and chemical factors. Michurin's method of crossing of geographically distant plants would be widely used by other selectionists. He worked out theoretical basis and some practical means for hybridization of geographically distant plants. Michurin also proposed means for overcoming the genetic barrier of incompatibility during the process of hybridization, such as pollination of the young hybrids during their first florescence, preliminary vegetative crossing, and use of a “mediator”, pollination with the mix of different kinds of pollen. The Soviets began to cultivate Michurin's hybrids of apple, pear, cherry, rowan and others. The variety Antonovka is the most famous apple he developed. It is so popular in Russia that it was given the name The People's Apple. It is widely used in Russia and Poland for fresh eating and culinary purposes. In other parts of Europe and North America, it is principally used as a hardyrootstock. Michurin also cultivated hybrids of grape, apricot, sweet cherry and other southern plants in the northern climates. One of the most highly cited phrases by Michurin was: "We cannot wait for favors from Nature. To take them from it – that is our task." During the Lysenkoism campaign, work by Michurin was misused, after his death, by Soviet propaganda as an argument against genetics. A pseudo-scientist, Lysenko claimed later to be the successor of the Michurin's school.
